6-butoxy-2-(2-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-2H-chromene-3-carboxylic acid methyl ester

Base Information

Chemical Name:6-butoxy-2-(2-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-2H-chromene-3-carboxylic acid methyl ester
CAS No.:1027236-21-0
Molecular Formula:C₂₃H₂₃F₃O₈S
Molecular Weight:516.492
Hs Code.:

6-butoxy-2-(2-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-2<i>H</i>-chromene-3-carboxylic acid methyl ester

Synonyms:6-butoxy-2-(2-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-2H-chromene-3-carboxylic acid methyl ester

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Chemical Property of 6-butoxy-2-(2-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-2H-chromene-3-carboxylic acid methyl ester

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Technology Process of 6-butoxy-2-(2-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-2H-chromene-3-carboxylic acid methyl ester

There total 4 articles about 6-butoxy-2-(2-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-2H-chromene-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145100-50-1
1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide

: (2R,3S)-6-Butoxy-2-(2-methoxy-phenyl)-4-oxo-chroman-3-carboxylic acid methyl ester

: 1027236-21-0
6-butoxy-2-(2-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-2H-chromene-3-carboxylic acid methyl ester

Guidance literature:: (2R,3S)-6-Butoxy-2-(2-methoxy-phenyl)-4-oxo-chroman-3-carboxylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide; In N,N-dimethyl-formamide; at 0 ℃; for 3h; Further stages.;
DOI:10.1021/jm010382z

Reference yield:

: 203919-46-4
6-butoxy-4-oxo-4H-chromene-3-carbaldehyde

: 1027236-21-0
6-butoxy-2-(2-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-2H-chromene-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. NaClO₂; NH₂SO₃H / CH₂Cl₂ / 0.5 h / 0 °C

2.1: (COCl)2; DMF / CH₂Cl₂ / 1 h / 20 °C

3.1: CH₂Cl₂ / 0.25 h

4.1: CuI / tetrahydrofuran / 0.25 h / 20 °C

4.2: tetrahydrofuran / 1 h / 0 °C

5.1: NaH / dimethylformamide / 1 h / 0 °C

5.2: dimethylformamide / 3 h / 0 °C

With sodium chlorite; copper(l) iodide; oxalyl dichloride; aminosulfonic acid; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010382z

Reference yield:

: 6-butoxy-4-oxo-4H-chromene-3-carbonyl chloride

: 1027236-21-0
6-butoxy-2-(2-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-2H-chromene-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / 0.25 h

2.1: CuI / tetrahydrofuran / 0.25 h / 20 °C

2.2: tetrahydrofuran / 1 h / 0 °C

3.1: NaH / dimethylformamide / 1 h / 0 °C

3.2: dimethylformamide / 3 h / 0 °C

With copper(l) iodide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010382z