14-(benzyloxy)tetradecanoic acid

Base Information

• Chemical Name: 14-(benzyloxy)tetradecanoic acid
• CAS No.: 137442-01-4
• Molecular Formula: C₂₁H₃₄O₃
• Molecular Weight: 334.499
• Mol file: 137442-01-4.mol

Synonyms:14-(benzyloxy)tetradecanoic acid

Chemical Property of 14-(benzyloxy)tetradecanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 14-(benzyloxy)tetradecanoic acid

There total 6 articles about 14-(benzyloxy)tetradecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

14-benzyloxy-tetradecan-1-al (286854-05-5) → 14-(benzyloxy)tetradecanoic acid (137442-01-4)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 5h;

DOI:10.1002/(SICI)1099-0690(200005)2000:10<1889::AID-EJOC1889>3.0.CO;2-R

Reference yield: 32.0%

1,14-tetradecanediol (19812-64-7) + benzyl chloride (100-44-7) → 1-((14-(benzyloxy)tetradecyloxy)methyl)benzene + 14-(benzyloxy)tetradecanoic acid (137442-01-4)

Guidance literature:

1,14-tetradecanediol; benzyl chloride; With potassium hydroxide; at 110 ℃; for 5h;

With chromium(VI) oxide; sulfuric acid; In acetone; at 20 ℃; for 4h;

Reference yield:

1,14-tetradecanediol (19812-64-7) → 14-(benzyloxy)tetradecanoic acid (137442-01-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent Turnov_. / KOH (powdered) / 5 h / 110 °C

2: 93 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

3: 94 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -60 - 0 °C

4: 99 percent / NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 5 h / 20 °C

With pyridine; potassium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; water; tert-butyl alcohol; 1: Alkylation / 2: Tosylation / 3: Oxidation / 4: Oxidation;

DOI:10.1002/(SICI)1099-0690(200005)2000:10<1889::AID-EJOC1889>3.0.CO;2-R

upstream raw materials:

14-benzyloxy-tetradecan-1-al

1,14-tetradecanediol

1,14-tetradecanedioic acid

tetradecane-1,14-diol monobenzyl ether

Downstream raw materials:

tert-butyl 14-(benzyloxy)tetradecanoate

C₃₁H₄₃NO₄

(5S)-3-(12'-benzyloxydodecyl)-5-methyldihydrofuran-2(3H)-one

(14S,17S,18S)-N-((3S,11bS)-9,11-bis(benzyloxy)-4-oxo-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-yl)-14,17,18-trihydroxyoctacosanamide