2-(4-morpholinyl)-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)acetamide

Base Information

Chemical Name:2-(4-morpholinyl)-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)acetamide
CAS No.:1309784-99-3
Molecular Formula:C₂₄H₂₄N₆O₄S
Molecular Weight:492.558
Hs Code.:

Synonyms:2-(4-morpholinyl)-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)acetamide

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Chemical Property of 2-(4-morpholinyl)-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)acetamide

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Technology Process of 2-(4-morpholinyl)-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)acetamide

There total 5 articles about 2-(4-morpholinyl)-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3235-69-6
morpholin-4-ylacetic acid

: 1198803-16-5
N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}benzenesulfonamide

: 1309784-99-3
2-(4-morpholinyl)-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)acetamide

Guidance literature:: morpholin-4-ylacetic acid; N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}benzenesulfonamide; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

With water; sodium hydroxide; In methanol; at 20 ℃; for 0.25h;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1309784-99-3
2-(4-morpholinyl)-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 0.08 h / 0 °C

1.2: 4 h / 0 °C

2.1: 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / N,N-dimethyl-formamide / 0.42 h / 20 - 120 °C / microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3.2: 0.25 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; HATU; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In N,N-dimethyl-formamide;

Reference yield:

: 885518-50-3
6-bromo-1H-indazole-4-amine

: 1309784-99-3
2-(4-morpholinyl)-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: 0.25 h / 20 °C

1.3: 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 120 °C / microwave irradiation

3.1: 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / N,N-dimethyl-formamide / 0.42 h / 20 - 120 °C / microwave irradiation

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4.2: 0.25 h / 20 °C

With sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In N,N-dimethyl-formamide; toluene; mineral oil;