5-(2-trifluoromethyl-4-chloro-benzyl)-1-([1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol

Base Information

Chemical Name:5-(2-trifluoromethyl-4-chloro-benzyl)-1-([1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol
CAS No.:1259500-56-5
Molecular Formula:C₁₈H₂₁ClF₃N₃O
Molecular Weight:387.832
Hs Code.:

Synonyms:5-(2-trifluoromethyl-4-chloro-benzyl)-1-([1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol

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Chemical Property of 5-(2-trifluoromethyl-4-chloro-benzyl)-1-([1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol

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Technology Process of 5-(2-trifluoromethyl-4-chloro-benzyl)-1-([1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol

There total 4 articles about 5-(2-trifluoromethyl-4-chloro-benzyl)-1-([1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-88-0
1,2,4-Triazole

: 1259500-55-4
C₁₅H₁₆ClF₃O

: 1774-47-6
trimethylsulfoxonium iodide

: 1259500-56-5
5-(2-trifluoromethyl-4-chloro-benzyl)-1-([1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol

Guidance literature:: 1,2,4-Triazole; trimethylsulfoxonium iodide; With sodium hydride; In 1-methyl-pyrrolidin-2-one; Inert atmosphere;

C₁₅H₁₆ClF₃O; In 1-methyl-pyrrolidin-2-one; isopropyl alcohol; at 100 ℃; for 4h;

Reference yield:

: 320-43-4
4-chloro-2-(trifluoromethyl)benzaldehyde

: 1259500-56-5
5-(2-trifluoromethyl-4-chloro-benzyl)-1-([1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol / 1.5 h / 0 - 20 °C

2.1: hydrogen / Ra-Ni / tetrahydrofuran / 10 h / 20 °C

3.1: sodium hydride / 1-methyl-pyrrolidin-2-one / Inert atmosphere

3.2: 4 h / 100 °C

With hydrogen; sodium hydride; sodium hydroxide; Ra-Ni; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; 1.1: Aldol Condensation;

Reference yield:

: 1259500-54-3
C₁₅H₁₄ClF₃O

: 1259500-56-5
5-(2-trifluoromethyl-4-chloro-benzyl)-1-([1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / Ra-Ni / tetrahydrofuran / 10 h / 20 °C

2.1: sodium hydride / 1-methyl-pyrrolidin-2-one / Inert atmosphere

2.2: 4 h / 100 °C

With hydrogen; sodium hydride; Ra-Ni; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;