320-43-4

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE is utilized as a precursor in the production of agrochemicals, playing a crucial role in the formulation of pesticides and other crop protection agents.
Used in Organic Synthesis:
4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE is employed as a building block in organic synthesis for the creation of diverse aromatic compounds, which have wide-ranging applications across various chemical and industrial processes.

InChI:InChI=1/C7H4BrF3O/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3,12H

Upstream product

• 707-72-2 o-trifluoromethyl-α,α-dichlorotoluene 
• 157229-44-2 o-trifluoromethyl-4-chloro-α,α-dichlorotoluene 
• 615-60-1 4-chloro-1,2-dimethylbenzene 
• 320-41-2 4-chloro-2-(trifluoromethyl)benzonitrile 

Downstream Products

• 211796-64-4 4-formyl-3-(trifluoromethyl)benzonitrile 
• 1253075-41-0 diethyl 2,6-bis(difluoromethyl)-4-(4-chloro-2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 1259500-54-3 C₁₅H₁₄ClF₃O 
• 771570-05-9 C₁₁H₄ClF₃N₂ 
• 1227682-50-9 C₂₆H₁₇Cl₂F₃N₆O₃ 
• 886496-75-9 1-(bromomethyl)-4-chloro-2-(trifluoromethyl)benzene 
• 98187-13-4 4-chloro-2-trifluoromethylbenzoyl chloride 
• 1203486-41-2 4-chloro-1-(dimethoxymethyl)-2-(trifluoromethyl)benzene 
• 773872-13-2 (4-chloro-2-(trifluoromethyl)phenyl)methanol 
• 1442445-19-3 (S)-N-(4-chloro-2-(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide 
• 1442445-09-1 ((R)-4-(1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-2-methylpiperazin-1-yl)((R)-pyrrolidin-2-yl)methanone 
• 1442445-44-4 C₃₁H₃₇ClF₃N₅O₃ 
• 1442445-43-3 1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole 

Relevant academic research and scientific papers

Intermediate compound for preparing 4-chloro-2-trifluoromethyl-acetophenone as well as preparation method and application of intermediate compound

The invention relates to an intermediate compound for preparing 4-chloro-2-trifluoromethyl-acetophenone as well as a preparation method and application of the intermediate compound. The intermediate compound is 2-(4-chloro-2-(trifluoromethyl) benzoyl) malonate, 3, 4-dimethylchlorobenzene is taken as an initial raw material, and the intermediate compound is obtained by chlorination, fluorine-chlorine exchange reaction, hydrolysis, continuous chlorination and coupling with malonate. The intermediate compound 2-(4-chloro-2-(trifluoromethyl) benzoyl) malonate is subjected to hydrolysis decarboxylation to obtain 4-chloro-2-trifluoromethyl-acetophenone, the raw materials in the route are easy to obtain, dangerous reactions such as nitration and Grignard reaction are avoided, and the method is suitable for industrial production.

2-benzoyl malonate compound as well as preparation method and application thereof

The invention discloses a 2-benzoyl malonate compound as well as a preparation method and application thereof. The invention provides a preparation method of an acetylbenzene compound shown as a formula III. The preparation method comprises the following step: in an organic solvent, in the presence of an acid and water, carrying out a deesterification reaction as shown in the specification on a 2-benzoyl malonate compound as shown in a formula I and/or a tautomer thereof to obtain the acetylbenzene compound as shown in a formula III, wherein X is F, Cl, Br or I; wherein R1 and R2 are each independently a C1-C4 alkyl group. By adopting the 2-benzoyl malonate compound disclosed by the invention, 4-halogenated-2-trifluoromethyl acetophenone can be prepared through one-step reaction, and the operation is simple and convenient.

Preparation method of o-trifluoromethyl-4-halogenobenzaldehyde and intermediate of o-trifluoromethyl-4-halogenobenzaldehyde

The invention discloses a preparation method of o-trifluoromethyl-4-halogenobenzaldehyde and an intermediate of the o-trifluoromethyl-4-halogenobenzaldehyde. The preparation method comprises that under solvent-free conditions, in the presence of an acid a

1-(HETERO)ARYL-3-AMINO-PYROLLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS

The present invention relates to compounds of the Formula (I) which are useful for treating conditions associated with mGluR3 receptors, such as depression, schizophrenia and migraine, pharmaceutical compositions thereof, and methods of using the same.