2-(S)-amino-3-(4-fluorobenzyl)-1-(3-(S)-hydroxypyrrolidin-1-yl)propan-1-one hydrochloride

Base Information

Chemical Name:2-(S)-amino-3-(4-fluorobenzyl)-1-(3-(S)-hydroxypyrrolidin-1-yl)propan-1-one hydrochloride
CAS No.:800402-04-4
Molecular Formula:C₁₃H₁₇FN₂O₂*ClH
Molecular Weight:288.75
Hs Code.:

Synonyms:2-(S)-amino-3-(4-fluorobenzyl)-1-(3-(S)-hydroxypyrrolidin-1-yl)propan-1-one hydrochloride

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Chemical Property of 2-(S)-amino-3-(4-fluorobenzyl)-1-(3-(S)-hydroxypyrrolidin-1-yl)propan-1-one hydrochloride

Chemical Property:

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Technology Process of 2-(S)-amino-3-(4-fluorobenzyl)-1-(3-(S)-hydroxypyrrolidin-1-yl)propan-1-one hydrochloride

There total 2 articles about 2-(S)-amino-3-(4-fluorobenzyl)-1-(3-(S)-hydroxypyrrolidin-1-yl)propan-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 800402-03-3
[1-(S)-(4-fluorobenzyl)-2-(3-(S)-hydroxypyrrolidin-1-yl)-2-oxoethyl]carbamic acid tert-butyl ester

: 800402-04-4
2-(S)-amino-3-(4-fluorobenzyl)-1-(3-(S)-hydroxypyrrolidin-1-yl)propan-1-one hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 18h;

Reference yield:

: 41153-30-4,57292-45-2,79561-25-4,129101-25-3
Boc-Phe(p-F)

: 800402-04-4
2-(S)-amino-3-(4-fluorobenzyl)-1-(3-(S)-hydroxypyrrolidin-1-yl)propan-1-one hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 0.17 h / 20 °C

1.2: 20 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; methanol / 18 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide);

Reference yield:

: 800401-84-7
5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

: 800402-04-4
2-(S)-amino-3-(4-fluorobenzyl)-1-(3-(S)-hydroxypyrrolidin-1-yl)propan-1-one hydrochloride

: 5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid [1-(S)-(4-fluorobenzyl)-2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl]amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 16h;