N-{1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethyl}-2,6-difluoro-benzamide

Base Information

Chemical Name:N-{1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethyl}-2,6-difluoro-benzamide
CAS No.:1433905-35-1
Molecular Formula:C₁₈H₁₄ClF₅N₂O
Molecular Weight:404.767
Hs Code.:

Synonyms:N-{1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethyl}-2,6-difluoro-benzamide

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Chemical Property of N-{1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethyl}-2,6-difluoro-benzamide

Chemical Property:

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Technology Process of N-{1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethyl}-2,6-difluoro-benzamide

There total 5 articles about N-{1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethyl}-2,6-difluoro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433906-72-9
1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethylamine

: 18063-02-0
2,6-difluorobenzoylchloride

: 1433905-35-1
N-{1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethyl}-2,6-difluoro-benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 1433906-77-4
2-methyl-propane-2-sulfinic acid 1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-methylidene amide

: 1433905-35-1
N-{1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethyl}-2,6-difluoro-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane; diethyl ether / 18 h / -48 - 20 °C

1.2: 2 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With triethylamine; In diethyl ether; dichloromethane;

Reference yield:

: 1433906-75-2
1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropanecarbonitrile

: 1433905-35-1
N-{1-[1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropyl]-ethyl}-2,6-difluoro-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 144 h / -78 - 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 24 h / 20 °C

3.1: dichloromethane; diethyl ether / 18 h / -48 - 20 °C

3.2: 2 h / 20 °C

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With titanium(IV) tetraethanolate; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;