(Z)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one O-methyl oxime

Base Information

• Chemical Name: (Z)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one O-methyl oxime
• CAS No.: 1616956-18-3
• Molecular Formula: C₁₆H₁₂N₂O₃
• Molecular Weight: 280.283
• Mol file: 1616956-18-3.mol

Synonyms:(Z)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one O-methyl oxime

Chemical Property of (Z)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one O-methyl oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one O-methyl oxime

There total 4 articles about (Z)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one O-methyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one (16616-39-0) + N-methoxylamine hydrochloride (593-56-6) → (Z)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one O-methyl oxime (1616956-18-3)

Guidance literature:

With pyridine; sodium sulfate; In methanol; Inert atmosphere;

DOI:10.1021/jo5008702

Reference yield:

(+/-)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-ol (88596-60-5) → (Z)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one O-methyl oxime (1616956-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide / acetone / 0.5 h / 20 °C / Inert atmosphere

2: sodium sulfate; pyridine / methanol / Inert atmosphere

With pyridine; manganese(IV) oxide; sodium sulfate; In methanol; acetone;

DOI:10.1021/jo5008702

Reference yield:

3-nitro-benzaldehyde (99-61-6) → (Z)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one O-methyl oxime (1616956-18-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: manganese(IV) oxide / acetone / 0.5 h / 20 °C / Inert atmosphere

3.1: sodium sulfate; pyridine / methanol / Inert atmosphere

With pyridine; manganese(IV) oxide; n-butyllithium; sodium sulfate; In tetrahydrofuran; methanol; hexane; acetone;

DOI:10.1021/jo5008702

upstream raw materials:

(+/-)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-ol

1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one

N-methoxylamine hydrochloride

3-nitro-benzaldehyde

Downstream raw materials:

3-(3-nitrophenyl)-5-phenyl-1,2-oxazole

4-fluoro-3-(3-nitrophenyl)-5-phenylisoxazole