<(3-Hydroxy-5-diphenylmethyloxycarbonyl)phenyl>-3-trifluoromethyl-3H-diazirine

Base Information

Chemical Name:<(3-Hydroxy-5-diphenylmethyloxycarbonyl)phenyl>-3-trifluoromethyl-3H-diazirine
CAS No.:136386-85-1
Molecular Formula:C₂₂H₁₅F₃N₂O₃
Molecular Weight:412.368
Hs Code.:

Synonyms:<(3-Hydroxy-5-diphenylmethyloxycarbonyl)phenyl>-3-trifluoromethyl-3H-diazirine

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Chemical Property of <(3-Hydroxy-5-diphenylmethyloxycarbonyl)phenyl>-3-trifluoromethyl-3H-diazirine

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Technology Process of <(3-Hydroxy-5-diphenylmethyloxycarbonyl)phenyl>-3-trifluoromethyl-3H-diazirine

There total 8 articles about <(3-Hydroxy-5-diphenylmethyloxycarbonyl)phenyl>-3-trifluoromethyl-3H-diazirine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 136386-84-0
<(3-Hydroxy-5-carboxy)phenyl>-3-trifluoromethyl-3H-diazirine

: 908093-98-1
diazodiphenylmethane

: 136386-85-1
<(3-Hydroxy-5-diphenylmethyloxycarbonyl)phenyl>-3-trifluoromethyl-3H-diazirine

Guidance literature:: In acetone; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(01)80991-1

Reference yield:

: 626-41-5
3,5-dibromophenol

: 136386-85-1
<(3-Hydroxy-5-diphenylmethyloxycarbonyl)phenyl>-3-trifluoromethyl-3H-diazirine

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂ / 1 h / Ambient temperature

2: 1) BuLi / 1) THF, -78 deg C, 0.5 h; 2) THF, -78 deg C, 0.5 h

3: 81 percent / NH₂OH*HCl, pyridine / ethanol / 4 h / Heating

4: 81 percent / pyridine / 3.5 h / Heating

5: 98 percent / NH₃ / diethyl ether / 8 h / -78 °C

6: 90 percent / RuO₂, NaIO₄ / CCl₄; H₂O; acetonitrile / Ambient temperature

7: 77 percent / 1M aq. LiOH / methanol / 3.5 h

8: 65 percent / acetone / 2 h / Ambient temperature

With pyridine; ruthenium(IV) oxide; lithium hydroxide; sodium periodate; n-butyllithium; hydroxylamine hydrochloride; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1016/S0040-4020(01)80991-1

Reference yield:

: 136386-79-3
(3,5-dibromophenoxy)-tert-butyldimethylsilane

: 136386-85-1
<(3-Hydroxy-5-diphenylmethyloxycarbonyl)phenyl>-3-trifluoromethyl-3H-diazirine

Guidance literature:: Multi-step reaction with 7 steps

1: 1) BuLi / 1) THF, -78 deg C, 0.5 h; 2) THF, -78 deg C, 0.5 h

2: 81 percent / NH₂OH*HCl, pyridine / ethanol / 4 h / Heating

3: 81 percent / pyridine / 3.5 h / Heating

4: 98 percent / NH₃ / diethyl ether / 8 h / -78 °C

5: 90 percent / RuO₂, NaIO₄ / CCl₄; H₂O; acetonitrile / Ambient temperature

6: 77 percent / 1M aq. LiOH / methanol / 3.5 h

7: 65 percent / acetone / 2 h / Ambient temperature

With pyridine; ruthenium(IV) oxide; lithium hydroxide; sodium periodate; n-butyllithium; hydroxylamine hydrochloride; ammonia; In methanol; tetrachloromethane; diethyl ether; ethanol; water; acetone; acetonitrile;
DOI:10.1016/S0040-4020(01)80991-1