136386-79-3Relevant academic research and scientific papers
COMPOSITIONS AND METHODS FOR INHIBITION OF CATHEPSINS
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Paragraph 0175; 0176; 0177, (2017/03/14)
This present disclosure is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin L, cathepsin K, and/or cathepsin B, will be therapeutically useful.
Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L
Parker, Erica N.,Odutola, Samuel O.,Wang, Yifan,Strecker, Tracy E.,Mukherjee, Rajeswari,Shi, Zhe,Chaplin, David J.,Trawick, Mary Lynn,Pinney, Kevin G.
supporting information, p. 1304 - 1310 (2017/06/19)
The magnitude of expression of cathepsin L, often upregulated in the tumor microenvironment, correlates with the invasive and metastatic nature of certain tumors. Inhibition of cathepsin L represents an emerging strategy for the treatment of metastatic ca
PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS
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Page/Page column 56, (2008/06/13)
The present invention describes phenoxy-acetic acids and pharmaceutical compositions containing the same and methods of using the same. The phenoxy-acetic acids are activators of PPAR-δ and should be useful for treating conditions mediated by the same.
The Synthesis Of Substituted Aryl Diazirines. A Bifunctional Reagent Suitable For Application To Photoaffinity Labelling Studies.
Baldwin, Jack E.,Jesudason, Cynthia D.,Moloney, Mark G.,Morgan, D. Rhys,Pratt, Andrew J.
, p. 5603 - 5614 (2007/10/02)
The 1,3,5-trisubstituted aryl diazirine (2) has been synthesised as a photoaffinity probe and has been elaborated to a reagent suitable for application to studies of penicillin and cephalosporin biosynthetic enzymes.Keywords: photoaffinity; diazirine; bif
