1,4-dihydro-N-(2-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

Base Information

Chemical Name:1,4-dihydro-N-(2-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide
CAS No.:103293-20-5
Molecular Formula:C₂₀H₂₀N₄O₄
Molecular Weight:380.403
Hs Code.:

Synonyms:1,4-dihydro-N-(2-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

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Chemical Property of 1,4-dihydro-N-(2-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

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Technology Process of 1,4-dihydro-N-(2-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

There total 3 articles about 1,4-dihydro-N-(2-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

: 1670-14-0
benzamidine monohydrochloride

: 103293-47-6
N-(2-hydroxyethyl)-2-(3-nitrophenylmethylene)-3-oxo-butanamide

: 103293-20-5
1,4-dihydro-N-(2-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

Guidance literature:: With triethylamine; In butan-1-ol; for 1h; Heating;
DOI:10.1248/cpb.40.2423

Reference yield:

: 24309-97-5
N-(2-hydroxyethyl)-3-oxobutanamide

: 103293-20-5
1,4-dihydro-N-(2-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89.8 percent / acetic acid, piperidine / benzene / 2.5 h / Heating

2: 91.3 percent / Et₃N / butan-1-ol / 1 h / Heating

With piperidine; acetic acid; triethylamine; In butan-1-ol; benzene;
DOI:10.1248/cpb.40.2423

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 103293-20-5
1,4-dihydro-N-(2-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89.8 percent / acetic acid, piperidine / benzene / 2.5 h / Heating

2: 91.3 percent / Et₃N / butan-1-ol / 1 h / Heating

With piperidine; acetic acid; triethylamine; In butan-1-ol; benzene;
DOI:10.1248/cpb.40.2423