24309-97-5

Basic information

• Product Name: N-(2-hydroxyethyl)acetoacetamide
• Synonyms: Acetoacet-N-hydroxyethylamide;beta-(N-Acetoacetylamino)ethanol;N-(2-Hydroxyethyl)-3-oxobutanamide;N-(2-hydroxyethyl)-3-keto-butyramide;N-(2-Hydroxy-ethyl)-3-oxo-butyramide
• CAS NO: 24309-97-5
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.1564
• EINECS: 246-149-7
• Mol File: 24309-97-5.mol

Chemical Properties

• Melting Point: 104-106 °C
• Boiling Point: 373.7 °C at 760 mmHg
• Flash Point: 179.8 °C
• Appearance: Yellow to brownisch solidifed melt
• Density: 1.132 g/cm³
• Vapor Pressure: 4.11E-07mmHg at 25°C
• Refractive Index: 1.459
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 11.48±0.46(Predicted)
• CAS DataBase Reference: N-(2-hydroxyethyl)acetoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxyethyl)acetoacetamide(24309-97-5)
• EPA Substance Registry System: N-(2-hydroxyethyl)acetoacetamide(24309-97-5)

Safety Data

• Hazardous Substances Data: 24309-97-5(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
N-(2-Hydroxyethyl)acetoacetamide is used as an intermediate for the synthesis of different organic chemicals, including quinoxaline derivatives. Its role in the synthesis process is crucial for the production of these chemicals, which have various applications in the chemical industry.
Used in Pharmaceutical Industry:
N-(2-Hydroxyethyl)acetoacetamide is used as a building block in the development of pharmaceutical compounds. Its unique chemical structure allows it to be a valuable component in the creation of new drugs with potential therapeutic applications.
Used in Research and Development:
In the field of research and development, N-(2-Hydroxyethyl)acetoacetamide is utilized for studying the properties and reactions of organic compounds. It can be employed in various experiments to better understand the behavior of similar molecules and their potential uses in various industries.
Used in Dye and Pigment Industry:
N-(2-Hydroxyethyl)acetoacetamide can be used as a starting material for the production of dyes and pigments. Its chemical properties make it suitable for the synthesis of colorants that can be used in various applications, such as textiles, plastics, and printing inks.
Used in Cosmetics Industry:
In the cosmetics industry, N-(2-Hydroxyethyl)acetoacetamide may be used as an ingredient in the formulation of various cosmetic products. Its properties can contribute to the development of products with improved performance and enhanced benefits for the end user.

InChI:InChI=1/C6H11NO3/c1-5(9)4-6(10)7-2-3-8/h8H,2-4H2,1H3,(H,7,10)

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Relevant articles and documents

Fe(III) Complex Compounds For The Treatment And Prophylaxis Of Iron Deficiency Symptoms And Iron Deficiency Anemias

The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.

Expedient synthesis of a 72-membered isoxazolino-β-ketoamide library by a 2·3-component reaction

An efficient 2·3-component reaction (2·3CR; a 2-component reaction followed, in one pot, by a3-component reaction) is presented for the synthesis of isoxazolino-β-ketoamides. This 2·3CR proceeds by (i) a Meldrum's acid-generated acyl ketene, which is trapped by an amine to form a β-ketoamide intermediate in a 2CR followed, in one pot, by (ii) a Mannich reaction followed by elimination of dimethyl amine·HCl to generate an α,β-unsaturated β-ketoamide dipolarophile that reacts in a nitrile oxide 1,3-dipolar cycloaddition reaction. This one-pot 2·3CR process delivers the targeted isoxazolino-β-ketoamide product. A total of 72 compounds are presented, all of which have been submitted to the NIH Molecular Libraries Small Molecule Repository for high-throughput biological screening.

6-FLUORO-7-(1-PIPERAZINYL)QUINOXALINE 1,4-DIOXIDES. PART I. 2-(N-2-HYDROXYALKYLCARBAMOYL) DERIVATIVES

A series of N--β-aminoalkanol 1,4-dioxides (12a-h) have been synthesized for bioassay via the Beirut reaction of 5(6)-fluoro-6(5)-(4-methyl-1-piperazinyl)benzofuroxan (9) with the appropriate N-acetoacetyl-β-aminoalkanol in the presence of triethylamine.Preliminary in vitro investigations have indicated that none of the title compounds exhibits any significant antibacterial potency at concentrations /= 200 μg/ml.