(2R^,6R^)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate

Base Information

Chemical Name:(2R^*,6R^*)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate
CAS No.:122624-19-5
Molecular Formula:C₂₃H₃₃NO₃
Molecular Weight:371.52
Hs Code.:

(2R<sup>*</sup>,6R<sup>*</sup>)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate

Synonyms:(2R^*,6R^*)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate

Suppliers and Price of (2R^*,6R^*)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R^*,6R^*)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R^*,6R^*)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate

There total 8 articles about (2R^*,6R^*)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 122624-12-8
(2R^*,6R^*)-methyl 1-benzyl-2-formyl-6-pentylpiperidine-2-carboxylate

: 1439-36-7
1-triphenylphosphoranylidene-2-propanone

: 122624-19-5
(2R^*,6R^*)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate

Guidance literature:: In toluene; at 110 ℃; for 40h;
DOI:10.1021/jo00279a034

Reference yield:

: 32362-97-3
2-pentylcyclohexanone

: 122624-19-5
(2R^*,6R^*)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 71 percent / hydroxylamine-O-sulfonic acid, formic acid / 1 h / Heating

2: 1.) t-BuOK / 1.) THF, RT, 10 min, 2.) THF, reflux, 1 h

3: 95 percent / Lawesson's reagent / hexamethylphosphoric acid triamide / 2.5 h / 100 °C

5: 2.) triethylamine / 1.) 65-70 deg C, 3 h, 2.) dichloromethane, RT, 1 h

6: 98 percent / Raney nickel W₂ / acetone / 4 h / Heating

7: 1.) bromine, 2.) water, triethylamine / 1.) ether, dichloromethane, -70 deg C, 1.5 h, 2.) RT, 2 h

8: 59 percent / toluene / 40 h / 110 °C

With Lawessons reagent; formic acid; potassium tert-butylate; water; bromine; triethylamine; hydroxylamine-O-sulfonic acid; Raney nickel W₂; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetone; toluene;
DOI:10.1021/jo00279a034

Reference yield:

: 84460-49-1
7-pentylhexahydroazepin-2-one

: 122624-19-5
(2R^*,6R^*)-(E)-methyl 1-benzyl-2-(3-oxobutenyl)-6-pentylpiperidine-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) t-BuOK / 1.) THF, RT, 10 min, 2.) THF, reflux, 1 h

2: 95 percent / Lawesson's reagent / hexamethylphosphoric acid triamide / 2.5 h / 100 °C

4: 2.) triethylamine / 1.) 65-70 deg C, 3 h, 2.) dichloromethane, RT, 1 h

5: 98 percent / Raney nickel W₂ / acetone / 4 h / Heating

6: 1.) bromine, 2.) water, triethylamine / 1.) ether, dichloromethane, -70 deg C, 1.5 h, 2.) RT, 2 h

7: 59 percent / toluene / 40 h / 110 °C

With Lawessons reagent; potassium tert-butylate; water; bromine; triethylamine; Raney nickel W₂; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetone; toluene;
DOI:10.1021/jo00279a034