C₂₇H₂₁N₅O₂

Base Information

Chemical Name:C₂₇H₂₁N₅O₂
CAS No.:1393736-25-8
Molecular Formula:C₂₇H₂₁N₅O₂
Molecular Weight:447.496
Hs Code.:

C<sub>27</sub>H<sub>21</sub>N<sub>5</sub>O<sub>2</sub>

Synonyms:C₂₇H₂₁N₅O₂

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Chemical Property of C₂₇H₂₁N₅O₂

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Technology Process of C₂₇H₂₁N₅O₂

There total 7 articles about C₂₇H₂₁N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1372407-05-0
C₂₆H₂₃N₅O₂

: 122-51-0
orthoformic acid triethyl ester

: 1393736-25-8
C₂₇H₂₁N₅O₂

Guidance literature:: With hydrogenchloride; In diethyl ether; water; N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm3007678

Reference yield:

: 1372129-84-4
5-chloro-N¹-(4-cyanophenyl)-4-methoxycarbonyl-2-nitroaniline

: 1393736-25-8
C₂₇H₂₁N₅O₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 190 °C / Microwave irradiation

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

2.2: 3 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; water; methanol / 4 h / 20 °C

3.2: pH 2 - 3

4.1: thionyl chloride / dichloromethane / 3 h / 20 °C / Reflux

5.1: tetrahydrofuran; water / 0.5 h / 0 °C

6.1: sodium dithionite; ammonium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

7.1: hydrogenchloride / N,N-dimethyl-formamide; water; diethyl ether / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; ammonium hydroxide; thionyl chloride; sodium dithionite; potassium tert-butylate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm3007678

Reference yield:

: 1372406-97-7
N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-methoxycarbonyl-2-nitroaniline

: 1393736-25-8
C₂₇H₂₁N₅O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / tetrahydrofuran; water; methanol / 4 h / 20 °C

1.2: pH 2 - 3

2.1: thionyl chloride / dichloromethane / 3 h / 20 °C / Reflux

3.1: tetrahydrofuran; water / 0.5 h / 0 °C

4.1: sodium dithionite; ammonium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

5.1: hydrogenchloride / N,N-dimethyl-formamide; water; diethyl ether / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; ammonium hydroxide; thionyl chloride; sodium dithionite; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm3007678