(R)-[2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[1,3]dioxol-5-yl]morpholin-4-ylmethanone

Base Information

Chemical Name:(R)-[2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[1,3]dioxol-5-yl]morpholin-4-ylmethanone
CAS No.:656804-84-1
Molecular Formula:C₂₄H₁₇Cl₂F₂NO₄
Molecular Weight:492.306
Hs Code.:

Synonyms:(R)-[2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[1,3]dioxol-5-yl]morpholin-4-ylmethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-[2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[1,3]dioxol-5-yl]morpholin-4-ylmethanone

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Technology Process of (R)-[2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[1,3]dioxol-5-yl]morpholin-4-ylmethanone

There total 3 articles about (R)-[2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[1,3]dioxol-5-yl]morpholin-4-ylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 110-91-8,99108-56-2
morpholine

: 656804-75-0
2-(2,4-dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)benzo[1,3]dioxole-5-carboxylic acid

: 656804-84-1
(R)-[2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[1,3]dioxol-5-yl]morpholin-4-ylmethanone

: 656804-86-3
(S)-[2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[1,3]dioxol-5-yl]morpholin-4-ylmethanone

Guidance literature:: 2-(2,4-dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)benzo[1,3]dioxole-5-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃;

morpholine; In N,N-dimethyl-formamide; at 90 ℃; for 8h; Further stages.;
DOI:10.1021/jm701487t

Reference yield:

: 15159-40-7
4-morpholinocarbonyl chloride

: 1020092-91-4
(R)-5-bromo-2-(2,4-dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)benzo[1,3]dioxole

: 656804-84-1
(R)-[2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[1,3]dioxol-5-yl]morpholin-4-ylmethanone

: 656804-86-3
(S)-[2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[1,3]dioxol-5-yl]morpholin-4-ylmethanone

Guidance literature:: (R)-5-bromo-2-(2,4-dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)benzo[1,3]dioxole; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 1h;

4-morpholinocarbonyl chloride; In tetrahydrofuran; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/jm701487t