1-(2-(methylmercapto)-pyrimidin-4-yl)-7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

Base Information

Chemical Name:1-(2-(methylmercapto)-pyrimidin-4-yl)-7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS No.:894792-12-2
Molecular Formula:C₁₉H₁₈N₄S
Molecular Weight:334.445
Hs Code.:

Synonyms:1-(2-(methylmercapto)-pyrimidin-4-yl)-7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

Suppliers and Price of 1-(2-(methylmercapto)-pyrimidin-4-yl)-7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2-(methylmercapto)-pyrimidin-4-yl)-7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2-(methylmercapto)-pyrimidin-4-yl)-7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

There total 5 articles about 1-(2-(methylmercapto)-pyrimidin-4-yl)-7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 49844-90-8
4-Chloro-2-methylthiopyrimidine

: 894791-94-7
7-phenyl-1,2,3,4-tetrahydro-1,5-naphthyridine

: 894792-12-2
1-(2-(methylmercapto)-pyrimidin-4-yl)-7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

Guidance literature:: With sodium methylate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 100 ℃; for 10h; Schlenk technique; Inert atmosphere;

Reference yield: 71.0%

: 49844-90-8
4-Chloro-2-methylthiopyrimidine

: 894792-11-1
7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

: 894792-12-2
1-(2-(methylmercapto)-pyrimidin-4-yl)-7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

Guidance literature:: With palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; at 100 ℃; for 10h; Reagent/catalyst; Solvent; Catalytic behavior; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.5b01976

Reference yield:

: 23612-57-9
(2-amino-3-pyridinyl)methanol

: 894792-12-2
1-(2-(methylmercapto)-pyrimidin-4-yl)-7-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; dodecacarbonyl-triangulo-triruthenium; potassium tert-butylate / tert-Amyl alcohol / 5 h / 130 °C / Schlenk technique; Inert atmosphere

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; sodium t-butanolate / toluene / 10 h / 100 °C / Inert atmosphere; Schlenk technique

With dodecacarbonyl-triangulo-triruthenium; potassium tert-butylate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tert-Amyl alcohol; toluene;
DOI:10.1021/acs.orglett.5b01976