23612-57-9

Basic information

• Product Name: (2-Aminopyridin-3-yl)methanol
• Synonyms: RARECHEM AL BD 1234;(2-AMINO-3-PYRIDINYL)METHANOL;2-AMINOPYRIDINE-3-METHANOL;(2-AMINO-PYRIDIN-3-YL)-METHANOL;(2-aminopyridine-3-yl)methanol;2-Amino-3-(hydroxymethyl)pyridine;4-(AMINOPYRIDINE-3-YL) METHANOL (2-AMINO-PYRIDIN-3-YL)-METHANOL;2-Amino-3-pyridinemethanol
• CAS NO: 23612-57-9
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• EINECS: -0
• Product Categories: pharmacetical;Hydroxymethyl's;Pyridines;Pyridine;Chemical Amines;Amines;Aromatics;Heterocycles;NULL;Heterocycle-Pyridine series
• Mol File: 23612-57-9.mol
• Article Data: 17

Chemical Properties

• Melting Point: 66-68°C
• Boiling Point: 320.7 °C at 760 mmHg
• Flash Point: 147.7 °C
• Appearance: light yellow crystal
• Density: 1.257 g/cm³
• Vapor Pressure: 0.00013mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 13.54±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: (2-Aminopyridin-3-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Aminopyridin-3-yl)methanol(23612-57-9)
• EPA Substance Registry System: (2-Aminopyridin-3-yl)methanol(23612-57-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 23612-57-9(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

Uses

(2-Aminopyridin-3-yl)methanol is an intermediate used in the synthesis of mirtazapine, an antidepressant.

InChI:InChI=1/C6H8N2O/c7-6-5(4-9)2-1-3-8-6/h1-3,9H,4H2,(H2,7,8)

Upstream product

• 504-29-0 2-aminopyridine 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 13362-26-0 2-aminopyridine-3-carboxylic acid ethyl ester 
• 86847-64-5 N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide 

Downstream Products

• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 116625-87-7 (4-nitrophenyl)(2-phenyl-1,8-naphthyridin-3-yl)methanone 
• 116625-77-5 (2-phenyl-1,8-naphthyridin-3-yl)(p-tolyl)methanone 
• 15936-02-4 2-phenyl-1,8-naphthyridine 

Relevant articles and documents

-

-

Alkenyl compound and its method and use thereof

The invention provides a new substituted alkenyl compound, pharmaceutically acceptable salts of the new substituted alkenyl compound, a medicinal preparation of the new substituted alkenyl compound, and application of the new substituted alkenyl compound, the pharmaceutically acceptable salts and the medicinal preparation of the new substituted alkenyl compound in aspects of regulating the activity of protein kinase and regulating the intercellular or intracellular signal response. The invention also relates to a medicament composition containing the compound at the same time, and relates to a method for treating high-proliferative diseases of mammals especially the human by using the medicament composition.

Method for preparing 2-amino-3-hydroxymethylpyridine

The invention discloses a method for preparing 2-amino-3-hydroxymethylpyridine, and belongs to the field of chemical synthesis. 2-aminopyridine and pivaloyl chloride are used as initial reactants to form intermediate product 2-pivalamidopyridine under the action of triethylamine, after hydrogen extraction by use of n-butyllithium, dimethylformamide is added for hydroformylation, and target product2-amino-3-hydroxymethylpyridine can be obtained by reduction with sodium borohydride. Raw materials used in the method are low in cost, and the method is simple in operation, short in synthesis process, mild in reaction conditions, high in yield, and suitable for large-scale industrial production.