2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

Base Information

Chemical Name:2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene
CAS No.:1244030-74-7
Molecular Formula:C₂₁H₁₇ClN₄OS
Molecular Weight:408.911
Hs Code.:

Synonyms:2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

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Technology Process of 2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

There total 5 articles about 2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 21278-77-3
2-(4-chlorophenyl)thiazole-4-carbaldehyde

: 109-77-3
malononitrile

: 99-07-0
3-Dimethylaminophenol

: 1244030-74-7
2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

Guidance literature:: With piperidine; In ethanol; at 35 ℃; for 12h;
DOI:10.1002/ardp.200900198

Reference yield:

: 36093-99-9
[2-(4-chloro-phenyl)-thiazol-4-yl]-methanol

: 1244030-74-7
2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / chloroform / 12 h / 20 °C

2: piperidine / ethanol / 12 h / 35 °C

With piperidine; manganese(IV) oxide; In ethanol; chloroform;
DOI:10.1002/ardp.200900198

Reference yield:

: 17969-22-1
4-chloromethyl-2-(4-chloro-phenyl)-thiazole

: 1244030-74-7
2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; water / Reflux

2: manganese(IV) oxide / chloroform / 12 h / 20 °C

3: piperidine / ethanol / 12 h / 35 °C

With piperidine; manganese(IV) oxide; sulfuric acid; water; In ethanol; chloroform;
DOI:10.1002/ardp.200900198