2-(4-Chlorophenyl)-1,3-thiazole-4-carbaldehyde

Base Information

Chemical Name:2-(4-Chlorophenyl)-1,3-thiazole-4-carbaldehyde
CAS No.:21278-77-3
Molecular Formula:C10H6ClNOS
Molecular Weight:223.683
Hs Code.:2934100090
DSSTox Substance ID:DTXSID10366604
Wikidata:Q82151890
Mol file:21278-77-3.mol

Synonyms:21278-77-3;2-(4-Chlorophenyl)thiazole-4-carbaldehyde;2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE;2-(4-chlorophenyl)-1,3-thiazole-4-carbaldehyde;SCHEMBL6211632;DTXSID10366604;QVEJNZQGJYCMKA-UHFFFAOYSA-N;MFCD06335185;AKOS000117553;AB23739;2-(4-chlorophenyl)thiazole-4-carboxaldehyde;CS-0307883;FT-0711220;2-(4-chlorophenyl)-thiazole-4-carboxaldehyde;EN300-09724;A19605;W-206613;Z56985769;2-(4-chloro-phenyl)-thiazole-4-carbaldehyde, AldrichCPR

Suppliers and Price of 2-(4-Chlorophenyl)-1,3-thiazole-4-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(4-Chlorophenyl)thiazole-4-carbaldehyde
100mg
$ 60.00

SynChem
2-(4-Chloro-phenyl)-thiazole-4-carbaldehyde 95+%
1 g
$ 155.00

SynChem
2-(4-Chloro-phenyl)-thiazole-4-carbaldehyde 95+%
5 g
$ 535.00

Matrix Scientific
2-(4-Chlorophenyl)thiazole-4-carbaldehyde
5g
$ 796.00

Matrix Scientific
2-(4-Chlorophenyl)thiazole-4-carbaldehyde
1g
$ 248.00

Matrix Scientific
2-(4-Chlorophenyl)thiazole-4-carbaldehyde
10g
$ 1272.00

J&W Pharmlab
2-(4-Chloro-phenyl)-thiazole-4-carbaldehyde 96%
25g
$ 1192.00

J&W Pharmlab
2-(4-Chloro-phenyl)-thiazole-4-carbaldehyde 96%
1g
$ 98.00

J&W Pharmlab
2-(4-Chloro-phenyl)-thiazole-4-carbaldehyde 96%
5g
$ 298.00

Crysdot
2-(4-Chlorophenyl)thiazole-4-carbaldehyde 95+%
5g
$ 673.00

Total 21 raw suppliers

Chemical Property of 2-(4-Chlorophenyl)-1,3-thiazole-4-carbaldehyde

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.653
Boiling Point:377.571 °C at 760 mmHg
PKA:-0.30±0.10(Predicted)
Flash Point:182.149 °C
PSA：58.20000
Density:1.388 g/cm³
LogP:3.27600
Storage Temp.:2-8°C
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:222.9858627
Heavy Atom Count:14
Complexity:206

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Chlorophenyl)thiazole-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36-43
Safety Statements: 26-36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC(=CS2)C=O)Cl

Technology Process of 2-(4-Chlorophenyl)-1,3-thiazole-4-carbaldehyde

There total 7 articles about 2-(4-Chlorophenyl)-1,3-thiazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 20287-70-1
ethyl 2-(2-(4-chlorophenyl)thiazol-4-yl)acetate

: 21278-77-3
2-(4-chlorophenyl)thiazole-4-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

Reference yield:

: 2521-24-6
4-chlorothiobenzamide

: 21278-77-3
2-(4-chlorophenyl)thiazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 24 h / Ambient temperature

2: aq. NaOH / methanol / 0.33 h

3: CrO₃, H₂SO₄ / acetone / 1 h / Ambient temperature

With chromium(VI) oxide; sodium hydroxide; sulfuric acid; In methanol; acetone;
DOI:10.1021/jm00280a012

Reference yield:

: 61786-00-3
ethyl 2-(4-chlorophenyl)thiazole-4-carboxylate

: 21278-77-3
2-(4-chlorophenyl)thiazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / 0 °C / Cooling with ice

2: iodoxy benzoic acid / dimethyl sulfoxide / 0 - 20 °C

With lithium aluminium tetrahydride; iodoxy benzoic acid; In diethyl ether; dimethyl sulfoxide;
DOI:10.1007/s00044-017-1955-1