(4R,5S)-4-allyl-5-tert-butyldiphenylsilyloxymethyl-3-tert-butoxycarbonyl-2,2-dimethyl-oxazolidine

Base Information

Chemical Name:(4R,5S)-4-allyl-5-tert-butyldiphenylsilyloxymethyl-3-tert-butoxycarbonyl-2,2-dimethyl-oxazolidine
CAS No.:905711-10-6
Molecular Formula:C₃₀H₄₃NO₄Si
Molecular Weight:509.761
Hs Code.:

Synonyms:(4R,5S)-4-allyl-5-tert-butyldiphenylsilyloxymethyl-3-tert-butoxycarbonyl-2,2-dimethyl-oxazolidine

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Chemical Property of (4R,5S)-4-allyl-5-tert-butyldiphenylsilyloxymethyl-3-tert-butoxycarbonyl-2,2-dimethyl-oxazolidine

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Technology Process of (4R,5S)-4-allyl-5-tert-butyldiphenylsilyloxymethyl-3-tert-butoxycarbonyl-2,2-dimethyl-oxazolidine

There total 3 articles about (4R,5S)-4-allyl-5-tert-butyldiphenylsilyloxymethyl-3-tert-butoxycarbonyl-2,2-dimethyl-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 905711-09-3
(2S,3R)-1-tert-butyldiphenylsilyloxy-3-tert-butoxycarbonylamino-5-hexen-2-ol

: 77-76-9
2,2-dimethoxy-propane

: 905711-10-6
(4R,5S)-4-allyl-5-tert-butyldiphenylsilyloxymethyl-3-tert-butoxycarbonyl-2,2-dimethyl-oxazolidine

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 85 ℃; for 4.5h;
DOI:10.1021/ol061022e

Reference yield:

: 905711-08-2
(2S,3R)-1-tert-butyldiphenylsilyloxy-3-tert-butoxycarbonylamino-2-(p-nitrobenzoyloxy)-5-hexene

: 905711-10-6
(4R,5S)-4-allyl-5-tert-butyldiphenylsilyloxymethyl-3-tert-butoxycarbonyl-2,2-dimethyl-oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / RedAl(R) / diethyl ether / 6 h / -20 °C

2: 70 percent / p-toluenesulfonic acid / toluene / 4.5 h / 85 °C

With toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In diethyl ether; toluene;
DOI:10.1021/ol061022e

Reference yield:

: 596108-85-9
(2S,3R)-1-tert-butyldiphenylsilyloxy-3-tert-butoxycarbonylamino-6-hexen-2-ol

: 905711-10-6
(4R,5S)-4-allyl-5-tert-butyldiphenylsilyloxymethyl-3-tert-butoxycarbonyl-2,2-dimethyl-oxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / PPh₃; DIAD / toluene / 0 - 20 °C

2: 72 percent / RedAl(R) / diethyl ether / 6 h / -20 °C

3: 70 percent / p-toluenesulfonic acid / toluene / 4.5 h / 85 °C

With di-isopropyl azodicarboxylate; toluene-4-sulfonic acid; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; In diethyl ether; toluene;
DOI:10.1021/ol061022e