2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-4-phenylthiazole

Base Information

Chemical Name:2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-4-phenylthiazole
CAS No.:1352834-57-1
Molecular Formula:C₂₆H₂₄N₂O₂S
Molecular Weight:428.555
Hs Code.:

Synonyms:2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-4-phenylthiazole

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Chemical Property of 2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-4-phenylthiazole

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Technology Process of 2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-4-phenylthiazole

There total 4 articles about 2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-4-phenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1373440-42-6
benzyl (1R,3S)-6,7-dimethoxy-1-phenyl-3-(4-phenyl-1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

: 1352834-57-1
2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-4-phenylthiazole

Guidance literature:: With propyl sulfide; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 3.5h; Inert atmosphere;

Reference yield:

: 1240163-16-9
(1R,3S)-2-(benzyloxycarbonyl)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 1352834-57-1
2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-4-phenylthiazole

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate / acetonitrile / 6 h / 20 °C / Inert atmosphere

2: Lawessons reagent / tetrahydrofuran / 16 h / 20 °C

3: calcium carbonate / methanol / Reflux

4: propyl sulfide; boron trifluoride diethyl etherate / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

With Lawessons reagent; pyridine; propyl sulfide; di-tert-butyl dicarbonate; boron trifluoride diethyl etherate; ammonium bicarbonate; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 1373440-40-4
benzyl (1R,3S)-3-carbamoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

: 1352834-57-1
2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-4-phenylthiazole

Guidance literature:: Multi-step reaction with 3 steps

1: Lawessons reagent / tetrahydrofuran / 16 h / 20 °C

2: calcium carbonate / methanol / Reflux

3: propyl sulfide; boron trifluoride diethyl etherate / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

With Lawessons reagent; propyl sulfide; boron trifluoride diethyl etherate; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane;