2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl dihydrogen phosphate

Base Information

Chemical Name:2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl dihydrogen phosphate
CAS No.:1429339-91-2
Molecular Formula:C₂₉H₃₀FN₆O₇PS
Molecular Weight:656.631
Hs Code.:

Synonyms:2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl dihydrogen phosphate

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Chemical Property of 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl dihydrogen phosphate

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Technology Process of 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl dihydrogen phosphate

There total 6 articles about 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1429340-27-1
di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate

: 1429339-91-2
2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl dihydrogen phosphate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 ℃; for 0.666667h;

Reference yield:

: 1342828-83-4
2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate

: 1429339-91-2
2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; methanol / tetrahydrofuran / 3 h / 20 °C

2.1: 1H-tetrazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: 0 - 20 °C

2.3: 0 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.67 h / 0 °C

With 1H-tetrazole; hydrogenchloride; methanol; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1341216-03-2
1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

: 1429339-91-2
2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-tetrazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: 0 - 20 °C

1.3: 0 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.67 h / 0 °C

With 1H-tetrazole; hydrogenchloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;