di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate

Base Information

Chemical Name:di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate
CAS No.:1429340-27-1
Molecular Formula:C₃₇H₄₆FN₆O₇PS
Molecular Weight:768.846
Hs Code.:

di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate

Synonyms:di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate

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Chemical Property of di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate

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Technology Process of di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate

There total 5 articles about di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1341216-03-2
1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

: 117924-33-1
di-tert-butyl N,N-diethylphosphoramidite

: 1429340-27-1
di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate

Guidance literature:: 1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea; di-tert-butyl N,N-diethylphosphoramidite; With 1H-tetrazole; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

With dihydrogen peroxide; In water; N,N-dimethyl-formamide; at 0 - 20 ℃;

With sodium metabisulfite; In water; N,N-dimethyl-formamide; at 0 ℃;

Reference yield:

: 1342828-83-4
2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate

: 1429340-27-1
di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; methanol / tetrahydrofuran / 3 h / 20 °C

2.1: 1H-tetrazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: 0 - 20 °C

2.3: 0 °C

With 1H-tetrazole; methanol; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1341216-04-3
tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazine-1-carboxylate

: 1429340-27-1
di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: sodium hydroxide; methanol / tetrahydrofuran / 3 h / 20 °C

4.1: 1H-tetrazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.2: 0 - 20 °C

4.3: 0 °C

With 1H-tetrazole; methanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;