1-(2-bromo-3,4,5-trimethoxybenzyl)-5-(3-methoxybenzyl)-3,4-dihydropyridin-2(1H)-one

Base Information

Chemical Name:1-(2-bromo-3,4,5-trimethoxybenzyl)-5-(3-methoxybenzyl)-3,4-dihydropyridin-2(1H)-one
CAS No.:1357295-72-7
Molecular Formula:C₂₃H₂₆BrNO₅
Molecular Weight:476.367
Hs Code.:

Synonyms:1-(2-bromo-3,4,5-trimethoxybenzyl)-5-(3-methoxybenzyl)-3,4-dihydropyridin-2(1H)-one

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Chemical Property of 1-(2-bromo-3,4,5-trimethoxybenzyl)-5-(3-methoxybenzyl)-3,4-dihydropyridin-2(1H)-one

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Technology Process of 1-(2-bromo-3,4,5-trimethoxybenzyl)-5-(3-methoxybenzyl)-3,4-dihydropyridin-2(1H)-one

There total 6 articles about 1-(2-bromo-3,4,5-trimethoxybenzyl)-5-(3-methoxybenzyl)-3,4-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 946071-56-3
2-bromo-3,4,5-trimethoxybenzylamine

: 1357295-65-8
ethyl 4-formyl-5-(3-methoxyphenyl)pentanoate

: 1357295-72-7
1-(2-bromo-3,4,5-trimethoxybenzyl)-5-(3-methoxybenzyl)-3,4-dihydropyridin-2(1H)-one

Guidance literature:: With acetic acid; In 1,2-dichloro-ethane; for 12h; Reflux;
DOI:10.1016/j.tet.2011.12.060

Reference yield:

: C₁₄H₁₉NO

: 1357295-72-7
1-(2-bromo-3,4,5-trimethoxybenzyl)-5-(3-methoxybenzyl)-3,4-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 4 h / 5 - 80 °C / Molecular sieve

1.2: 2 h / 23 - 80 °C

2.1: acetic acid / 1,2-dichloro-ethane / 12 h / Reflux

With acetic acid; In 1,2-dichloro-ethane; acetonitrile; 1.1: Michael addition;
DOI:10.1016/j.tet.2011.12.060

Reference yield:

: 766-85-8
3-methoxy-1-iodobenzene

: 1357295-72-7
1-(2-bromo-3,4,5-trimethoxybenzyl)-5-(3-methoxybenzyl)-3,4-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 40 °C

2.1: potassium carbonate / benzene / 8 h / 23 °C / Reflux

3.1: acetonitrile / 4 h / 5 - 80 °C / Molecular sieve

3.2: 2 h / 23 - 80 °C

4.1: acetic acid / 1,2-dichloro-ethane / 12 h / Reflux

With N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; sodium hydrogencarbonate; potassium carbonate; acetic acid; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; benzene; 1.1: Heck reaction / 3.1: Michael addition;
DOI:10.1016/j.tet.2011.12.060