946071-56-3

Upstream product

• 1198078-72-6 C₁₀H₁₂BrNO₄ 
• 81925-35-1 2-bromo-3,4,5-trimethoxybenzyl bromide 
• 73252-54-7 (2-bromo-3,4,5-trimethoxyphenyl)methanol 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 35274-53-4 2-bromo-3,4,5-tri-methoxybenzaldehyde 

Downstream Products

• 1185915-39-2 N-(2-bromo-3,4,5-trimethoxybenzyl) 1-(2,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide 
• 1185915-64-3 N-(2-bromo-3,4,5-trimethoxybenzyl) 1-(2,4-difluorophenyl)-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide 
• 1357295-75-0 1-(2-bromo-3,4,5-trimethoxybenzyl)-5-hexyl-3,4-dihydropyridin-2(1H)-one 
• 1357295-72-7 1-(2-bromo-3,4,5-trimethoxybenzyl)-5-(3-methoxybenzyl)-3,4-dihydropyridin-2(1H)-one 
• 1357295-83-0 8,9,10-trimethoxy-1-(3-methoxybenzyl)-2,6-dihydropyrido[2,1-a]isoindol-4(3H)-one 
• 1527501-68-3 N-(2-bromo-3,4,5-trimethoxybenzyl)-4-methylbenzenesulfonamide 
• 1527501-96-7 2,3,4-trimethoxy-6-tosyl-5,6-dihydroindolo[1,2-a]quinazoline 
• 955130-19-5 ethyl (E)-3-(2-bromo-3,4,5-trimethoxyphenyl)acrylate 

Relevant academic research and scientific papers

CuI-catalyzed coupling of gem-dibromovinylanilides and sulfonamides: An efficient method for the synthesis of 2-amidoindoles and indolo[1,2-a] quinazolines

A Cu(I)-catalyzed, intermolecular protocol for the synthesis of 2-amidoindoles and tetrahydroindolo[1,2-a]quinazolines in shorter time and high yields is reported. The key highlight of this disclosure is the formation of 2-amidoindole and tetrahydroindolo[1,2-a]quinazoline moieties directly from gem-dibromovinylanilides and sulfonamides in a one-pot fashion through the in situ formation of ynamides followed by a base-promoted intramolecular hydroamidation.

Tricyclic isoindolines by Heck cyclization

A series of 4-formyl esters 8a-d was prepared by Michael addition of an enamine with ethyl acrylate. A subsequent condensation with 2-bromobenzylamines 3 gave rise to cyclic enamides 9aa-dd. In a Heck cyclization reaction tricyclic isoindoles 10aa-dd were formed in good yields.

NOVEL MODULATORS OF PROTEIN KINASE SIGNALING

The present invention provides new tyrphostin derivatives acting as protein kinase (PK) and receptor kinase (RK) signaling modulators. The invention further provides methods of their preparation, pharmaceutical compositions including such compounds, and m