5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-1-methyl-1,4-dihydro-4-quinolinone

Base Information

Chemical Name:5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-1-methyl-1,4-dihydro-4-quinolinone
CAS No.:645390-00-7
Molecular Formula:C₁₈H₁₇NO₄
Molecular Weight:311.337
Hs Code.:

Synonyms:5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-1-methyl-1,4-dihydro-4-quinolinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-1-methyl-1,4-dihydro-4-quinolinone

Chemical Property:

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Technology Process of 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-1-methyl-1,4-dihydro-4-quinolinone

There total 3 articles about 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-1-methyl-1,4-dihydro-4-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 645389-96-4
5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-1,4-dihydro-4-quinolinone

: 74-88-4
methyl iodide

: 645390-00-7
5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-1-methyl-1,4-dihydro-4-quinolinone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2003.09.094

Reference yield:

: 10272-07-8
3.5-dimethoxyaniline

: 645390-00-7
5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-1-methyl-1,4-dihydro-4-quinolinone

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / p-toluenesulfonic acid / ethanol / 24 h / Heating

2: 62 percent / xylene / 8 h / 240 - 250 °C

3: 85 percent / HBr / H₂O; dimethylformamide / 2.5 h / 90 °C

4: 70 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

With hydrogen bromide; potassium carbonate; toluene-4-sulfonic acid; In ethanol; water; N,N-dimethyl-formamide; xylene;
DOI:10.1016/j.tet.2003.09.094

Reference yield:

: 860233-40-5,258353-98-9
5,7-dimethoxy-2-(4-methoxyphenyl)-1,4-dihydro-4-quinolinone

: 645390-00-7
5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-1-methyl-1,4-dihydro-4-quinolinone

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / HBr / H₂O; dimethylformamide / 2.5 h / 90 °C

2: 70 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

With hydrogen bromide; potassium carbonate; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2003.09.094