(1R,2R)-ethyl 2-((R)-(4-methoxybenzyloxy)(phenyl)methyl)-cyclopropanecarboxylate

Base Information

Chemical Name:(1R,2R)-ethyl 2-((R)-(4-methoxybenzyloxy)(phenyl)methyl)-cyclopropanecarboxylate
CAS No.:1394818-63-3
Molecular Formula:C₂₁H₂₄O₄
Molecular Weight:340.419
Hs Code.:

Synonyms:(1R,2R)-ethyl 2-((R)-(4-methoxybenzyloxy)(phenyl)methyl)-cyclopropanecarboxylate

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Chemical Property of (1R,2R)-ethyl 2-((R)-(4-methoxybenzyloxy)(phenyl)methyl)-cyclopropanecarboxylate

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Technology Process of (1R,2R)-ethyl 2-((R)-(4-methoxybenzyloxy)(phenyl)methyl)-cyclopropanecarboxylate

There total 6 articles about (1R,2R)-ethyl 2-((R)-(4-methoxybenzyloxy)(phenyl)methyl)-cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1394818-62-2
(S)-2-((S)-(4-methoxybenzyloxy)(phenyl)methyl)oxirane

: 1394818-63-3
(1R,2R)-ethyl 2-((R)-(4-methoxybenzyloxy)(phenyl)methyl)-cyclopropanecarboxylate

Guidance literature:: With diethoxyphosphoryl-acetic acid ethyl ester; sodium hydride; In toluene; mineral oil; at 80 - 110 ℃; for 14h; stereoselective reaction;
DOI:10.1039/c2ob25622c

Reference yield: 75.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 1394818-62-2
(S)-2-((S)-(4-methoxybenzyloxy)(phenyl)methyl)oxirane

: 1394818-63-3
(1R,2R)-ethyl 2-((R)-(4-methoxybenzyloxy)(phenyl)methyl)-cyclopropanecarboxylate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In toluene; at 20 ℃;

(S)-2-((S)-(4-methoxybenzyloxy)(phenyl)methyl)oxirane; In toluene; at 80 - 110 ℃; for 14h; stereoselective reaction;
DOI:10.1039/c2ob25622c

Reference yield:

: 104-54-1
3-Phenylpropenol

: 1394818-63-3
(1R,2R)-ethyl 2-((R)-(4-methoxybenzyloxy)(phenyl)methyl)-cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; potassium hexacyanoferrate(III); hydroquinidein 1,4-phthalazinediyl diether; osmium(VIII) oxide; methanesulfonamide / water; toluene; tert-butyl alcohol / 30 h / 0 °C

2.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / methanol / 0.25 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

4.2: 6 h / 0 - 20 °C

5.1: sodium hydride / toluene / 20 °C

5.2: 14 h / 80 - 110 °C

With osmium(VIII) oxide; methanesulfonamide; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; dichloromethane; water; toluene; tert-butyl alcohol; 1.1: |Sharpless Dihydroxylation;
DOI:10.1039/c2ob25622c