{1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidin-4-yl}-(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:{1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidin-4-yl}-(4-methylpiperazin-1-yl)methanone
CAS No.:1380796-77-9
Molecular Formula:C₂₃H₂₉ClN₄O
Molecular Weight:412.962
Hs Code.:

Synonyms:{1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidin-4-yl}-(4-methylpiperazin-1-yl)methanone

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Chemical Property of {1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidin-4-yl}-(4-methylpiperazin-1-yl)methanone

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Technology Process of {1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidin-4-yl}-(4-methylpiperazin-1-yl)methanone

There total 12 articles about {1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidin-4-yl}-(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 109-01-3
1-methyl-piperazine

: 1380796-87-1
1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid

: 1380796-77-9
{1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidin-4-yl}-(4-methylpiperazin-1-yl)methanone

Guidance literature:: 1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In ethyl acetate; at 20 - 50 ℃; for 1h;

1-methyl-piperazine; In ethyl acetate; at 50 ℃; for 2h; Reagent/catalyst; Solvent;
DOI:10.1021/op300170q

Reference yield:

: 105884-19-3
1-(2-bromo-5-chlorophenyl)ethan-1-one

: 1380796-77-9
{1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidin-4-yl}-(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine / Isopropyl acetate / 5 - 10 °C

1.2: Reflux

2.1: ammonium acetate; acetic acid / ethanol / -4 °C / Reflux

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 45 - 110 °C / Inert atmosphere

4.1: sodium hydroxide; water / 1,4-dioxane / -4 - 80 °C

5.1: 1,1'-carbonyldiimidazole / dichloromethane / 20 °C / Inert atmosphere

5.2: 72 h / 4 - 20 °C

With ammonium acetate; water; iodine; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; palladium diacetate; In 1,4-dioxane; ethanol; dichloromethane; Isopropyl acetate; toluene;

Reference yield:

: 74534-15-9
1-chloro-2-iodo-4-nitrobenzene

: 1380796-77-9
{1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidin-4-yl}-(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 2,4-dichlorophenoxyacetic acid dimethylamine / 30 h / 60 °C / Inert atmosphere

2.1: hydrogenchloride; tin(ll) chloride / ethanol; water / 3 h / 60 °C

2.2: 0 °C

3.1: sodium nitrite; hydrogen bromide / water / 0 - 20 °C

3.2: -5 - 20 °C

3.3: -5 °C

4.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 45 - 110 °C / Inert atmosphere

5.1: sodium hydroxide; water / 1,4-dioxane / -4 - 80 °C

6.1: 1,1'-carbonyldiimidazole / dichloromethane / 20 °C / Inert atmosphere

6.2: 72 h / 4 - 20 °C

With hydrogenchloride; water; hydrogen bromide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; 1,1'-carbonyldiimidazole; tin(ll) chloride; sodium hydroxide; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In 1,4-dioxane; ethanol; dichloromethane; water; 2,4-dichlorophenoxyacetic acid dimethylamine; toluene;