1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid

Base Information

Chemical Name:1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid
CAS No.:1380796-87-1
Molecular Formula:C₁₈H₁₉ClN₂O₂
Molecular Weight:330.814
Hs Code.:

Synonyms:1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid

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Chemical Property of 1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid

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Technology Process of 1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid

There total 10 articles about 1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1380796-86-0
1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester

: 1380796-87-1
1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; for 15h; Reagent/catalyst; Reflux;
DOI:10.1021/op300170q

Reference yield:

: 105884-19-3
1-(2-bromo-5-chlorophenyl)ethan-1-one

: 1380796-87-1
1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine / Isopropyl acetate / 5 - 10 °C

1.2: Reflux

2.1: ammonium acetate; acetic acid / ethanol / -4 °C / Reflux

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 45 - 110 °C / Inert atmosphere

4.1: sodium hydroxide; water / 1,4-dioxane / -4 - 80 °C

With ammonium acetate; water; iodine; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium hydroxide; palladium diacetate; In 1,4-dioxane; ethanol; Isopropyl acetate; toluene;

Reference yield:

: 1190947-45-5
2-(2-chloro-5-nitro-phenyl)-5-methyl-pyridine

: 1380796-87-1
1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; tin(ll) chloride / ethanol; water / 3 h / 60 °C

1.2: 0 °C

2.1: sodium nitrite; hydrogen bromide / water / 0.5 h / 0 - 20 °C

2.2: 1 h / -5 - 20 °C

2.3: -5 °C

3.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 2 h / 110 °C / Inert atmosphere

4.1: sodium hydroxide / 1,4-dioxane / 3 h / 80 °C

With hydrogenchloride; hydrogen bromide; caesium carbonate; tin(ll) chloride; sodium hydroxide; sodium nitrite; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; ethanol; water; toluene;