5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-1-ylamine

Base Information

Chemical Name:5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-1-ylamine
CAS No.:1353967-59-5
Molecular Formula:C₂₄H₁₇FN₄O
Molecular Weight:396.424
Hs Code.:

Synonyms:5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-1-ylamine

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Chemical Property of 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-1-ylamine

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Technology Process of 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-1-ylamine

There total 4 articles about 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-1-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353970-14-5
2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine

: 1353967-90-4
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-3-ylamine

: 1353967-59-5
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-1-ylamine

Guidance literature:: 2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine; With pyridine; methanesulfonyl chloride; at 20 ℃; for 16h;

With ethanolamine; at 20 ℃; for 16h;

Reference yield:

: 63927-23-1
5-bromo-8-nitroisoquinoline

: 1353967-90-4
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-3-ylamine

: 1353967-59-5
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-1-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium bis(monoperoxyphthalate)hexahydrate / isopropyl alcohol / 144 h / 20 °C

2.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

3.1: 18 h / 60 °C / Inert atmosphere

4.1: methanesulfonyl chloride; pyridine / 16 h / 20 °C

4.2: 16 h / 20 °C

With pyridine; magnesium bis(monoperoxyphthalate)hexahydrate; sodium hydrogencarbonate; methanesulfonyl chloride; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1353970-10-1
5-bromo-8-nitro-isoquinoline 2-oxide

: 1353967-90-4
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-3-ylamine

: 1353967-59-5
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-8-methoxy-isoquinolin-1-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

2.1: 18 h / 60 °C / Inert atmosphere

3.1: methanesulfonyl chloride; pyridine / 16 h / 20 °C

3.2: 16 h / 20 °C

With pyridine; sodium hydrogencarbonate; methanesulfonyl chloride; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide;