2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine

Base Information

Chemical Name:2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine
CAS No.:1353970-14-5
Molecular Formula:C₂₄H₁₆FN₃O₂
Molecular Weight:397.408
Hs Code.:

Synonyms:2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine

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Chemical Property of 2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine

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Technology Process of 2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine

There total 4 articles about 2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353970-11-2
2-(2-fluoro-phenyl)-4-(8-nitro-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine

: 865-33-8
potassium methanolate

: 1353970-14-5
2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine

Guidance literature:: In methanol; at 60 ℃; for 18h; Inert atmosphere;

Reference yield:

: 67-56-1
methanol

: 1353970-11-2
2-(2-fluoro-phenyl)-4-(8-nitro-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine

: 865-33-8
potassium methanolate

: 1353970-14-5
2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine

Guidance literature:: at 60 ℃; for 18h; Inert atmosphere;

Reference yield:

: 63927-23-1
5-bromo-8-nitroisoquinoline

: 1353970-14-5
2-(2-fluoro-phenyl)-4-(8-methoxy-2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: magnesium bis(monoperoxyphthalate)hexahydrate / isopropyl alcohol / 144 h / 20 °C

2: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

3: 18 h / 60 °C / Inert atmosphere

With magnesium bis(monoperoxyphthalate)hexahydrate; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; isopropyl alcohol;