allyl N-(benzyloxycarbonyl)-O-<-(N,O-dimethyl-L-tyrosyl)>-L-threoninate

Base Information

• Chemical Name: allyl N-(benzyloxycarbonyl)-O-<-(N,O-dimethyl-L-tyrosyl)>-L-threoninate
• CAS No.: 117710-14-2
• Molecular Formula: C₃₆H₄₇N₃O₁₀
• Molecular Weight: 681.783

Synonyms:allyl N-(benzyloxycarbonyl)-O-<-(N,O-dimethyl-L-tyrosyl)>-L-threoninate

Chemical Property of allyl N-(benzyloxycarbonyl)-O-<-(N,O-dimethyl-L-tyrosyl)>-L-threoninate

Chemical Property:

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Technology Process of allyl N-(benzyloxycarbonyl)-O-<-(N,O-dimethyl-L-tyrosyl)>-L-threoninate

There total 2 articles about allyl N-(benzyloxycarbonyl)-O-<-(N,O-dimethyl-L-tyrosyl)>-L-threoninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

symmetric anhydride of Boc-Pro-OH (33294-56-3) + (S)-2-Benzyloxycarbonylamino-3-[(S)-3-(4-methoxy-phenyl)-2-methylamino-propionyloxy]-butyric acid allyl ester (117710-22-2) → allyl N-(benzyloxycarbonyl)-O-<-(N,O-dimethyl-L-tyrosyl)>-L-threoninate (117710-14-2)

Guidance literature:

at 130 ℃; for 0.0833333h;

DOI:10.1021/jo00264a022

Reference yield: 60.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + (S)-2-Benzyloxycarbonylamino-3-[(S)-3-(4-methoxy-phenyl)-2-methylamino-propionyloxy]-butyric acid allyl ester; compound with trifluoro-acetic acid (117710-23-3) → allyl N-(benzyloxycarbonyl)-O-<-(N,O-dimethyl-L-tyrosyl)>-L-threoninate (117710-14-2)

Guidance literature:

With dicyclohexyl-carbodiimide; at 0 ℃; for 24h;

DOI:10.1021/jo00264a022

Reference yield:

allyl N-(benzyloxycarbonyl)-O-<-(N,O-dimethyl-L-tyrosyl)>-L-threoninate (117710-14-2) + trifluoroacetic acid (76-05-1) → (S)-2-Benzyloxycarbonylamino-3-{(S)-3-(4-methoxy-phenyl)-2-[methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionyloxy}-butyric acid allyl ester; compound with trifluoro-acetic acid (117710-25-5)

Guidance literature:

for 0.5h;

DOI:10.1021/jo00264a022

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

(S)-2-Benzyloxycarbonylamino-3-[(S)-3-(4-methoxy-phenyl)-2-methylamino-propionyloxy]-butyric acid allyl ester; compound with trifluoro-acetic acid

symmetric anhydride of Boc-Pro-OH

(S)-2-Benzyloxycarbonylamino-3-[(S)-3-(4-methoxy-phenyl)-2-methylamino-propionyloxy]-butyric acid allyl ester

Downstream raw materials:

(S)-2-Benzyloxycarbonylamino-3-{(S)-3-(4-methoxy-phenyl)-2-[methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionyloxy}-butyric acid allyl ester; compound with trifluoro-acetic acid

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