(R)-2-chloro-6-(2-fluoroethyl)-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine

Base Information

Chemical Name:(R)-2-chloro-6-(2-fluoroethyl)-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine
CAS No.:1255701-26-8
Molecular Formula:C₁₅H₁₅ClFN₃O
Molecular Weight:307.755
Hs Code.:

Synonyms:(R)-2-chloro-6-(2-fluoroethyl)-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine

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Chemical Property of (R)-2-chloro-6-(2-fluoroethyl)-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine

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Technology Process of (R)-2-chloro-6-(2-fluoroethyl)-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine

There total 2 articles about (R)-2-chloro-6-(2-fluoroethyl)-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 762-49-2
2-fluoroethyl bromide

: 1255701-27-9
(R)-2-chloro-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine

: 1255701-26-8
(R)-2-chloro-6-(2-fluoroethyl)-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 7627-44-3
2, 4-dichloro-5-(iodomethyl)pyrimidine

: 1255701-26-8
(R)-2-chloro-6-(2-fluoroethyl)-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -78 °C

1.2: 20 °C / Cooling with ice-water bath

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;