benzyl 1-(3-chloro-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl)-1H-indole-5-carboxylate

Base Information

Chemical Name:benzyl 1-(3-chloro-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl)-1H-indole-5-carboxylate
CAS No.:1312312-52-9
Molecular Formula:C₃₆H₃₄ClNO₁₂
Molecular Weight:708.118
Hs Code.:

Synonyms:benzyl 1-(3-chloro-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl)-1H-indole-5-carboxylate

Suppliers and Price of benzyl 1-(3-chloro-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl)-1H-indole-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl 1-(3-chloro-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl)-1H-indole-5-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl 1-(3-chloro-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl)-1H-indole-5-carboxylate

There total 4 articles about benzyl 1-(3-chloro-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl)-1H-indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1312312-40-5
2-chloro-4-iodophenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside

: 108-24-7
acetic anhydride

: 136564-69-7
1H-indole-5-carboxylic acid benzyl ester

: 1312312-52-9
benzyl 1-(3-chloro-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl)-1H-indole-5-carboxylate

Guidance literature:: 2-chloro-4-iodophenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside; 1H-indole-5-carboxylic acid benzyl ester; With potassium phosphate; trans-1,2-cyclohexanediamine; copper(l) iodide; In 1,4-dioxane; at 105 ℃; Sealed tube; Inert atmosphere;

acetic anhydride; With dmap;

Reference yield: 40.0%

: 1312312-40-5
2-chloro-4-iodophenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside

: 136564-69-7
1H-indole-5-carboxylic acid benzyl ester

: 1312312-52-9
benzyl 1-(3-chloro-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl)-1H-indole-5-carboxylate

Guidance literature:: 2-chloro-4-iodophenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside; 1H-indole-5-carboxylic acid benzyl ester; With potassium phosphate; trans cyclohexane-1,2-diamine; In 1,4-dioxane; at 105 ℃; Inert atmosphere; Sealed tube;

With pyridine; dmap; acetic anhydride; for 2h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm300192x

Reference yield:

: 116130-33-7
2-chloro-4-iodophenol

: 1312312-52-9
benzyl 1-(3-chloro-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl)-1H-indole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / toluene / 2 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: potassium phosphate; trans cyclohexane-1,2-diamine / 1,4-dioxane / 105 °C / Inert atmosphere; Sealed tube

2.2: 2 h / Inert atmosphere; Sealed tube

With potassium phosphate; trans cyclohexane-1,2-diamine; trimethylsilyl trifluoromethanesulfonate; In 1,4-dioxane; toluene;
DOI:10.1021/jm300192x