5-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide hydrochloride

Base Information

Chemical Name:5-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide hydrochloride
CAS No.:1262855-66-2
Molecular Formula:C₁₇H₁₄BrF₃N₄O₂*ClH
Molecular Weight:479.684
Hs Code.:

Synonyms:5-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide hydrochloride

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Chemical Property of 5-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide hydrochloride

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Technology Process of 5-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide hydrochloride

There total 14 articles about 5-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-08-4
(5-{5-[(5-bromo-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

: 1262855-66-2
5-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 50 ℃; for 3.25h;

Reference yield:

: hydrochloride salt of 2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol

: 79-04-9
chloroacetyl chloride

: 1262855-66-2
5-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide hydrochloride

Guidance literature:: In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1262855-66-2
5-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 12 steps

1.1: toluene / 18 h / 90 °C

1.2: 1 h / -78 - -60 °C

2.1: sodium hydrogencarbonate; ozone / methanol; dichloromethane; oxygen / 0.17 h / -78 °C

2.2: 0.67 h / -78 - 0 °C

2.3: Cooling with ice

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: sodium carbonate / dichloromethane; water / 1 h / Cooling with ice

5.1: potassium tert-butylate / tert-butyl alcohol / 3 h / Reflux

6.1: Lawessons reagent / tetrahydrofuran / 1 h / Reflux

7.1: ammonia / methanol / 6 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 20 °C / Cooling with ice

9.1: sodium azide; sodium L-ascorbate / copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / ethanol; water / 70 °C / Inert atmosphere

10.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol

11.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

12.1: hydrogenchloride / 1,4-dioxane; methanol / 3.25 h / 50 °C

With Lawessons reagent; hydrogenchloride; sodium azide; 1-hydroxy-7-aza-benzotriazole; potassium tert-butylate; ammonia; hydrogen; sodium hydrogencarbonate; sodium carbonate; ozone; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; copper(l) iodide; palladium 10% on activated carbon; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; oxygen; toluene; tert-butyl alcohol;