benzyl (2-(diethoxyphosphoryl)-1,1,1-trifluoro-5-phenylpent-4-yn-2-yl)(prop-2-yn-1-yl)carbamate

Base Information

Chemical Name:benzyl (2-(diethoxyphosphoryl)-1,1,1-trifluoro-5-phenylpent-4-yn-2-yl)(prop-2-yn-1-yl)carbamate
CAS No.:1452510-62-1
Molecular Formula:C₂₆H₂₇F₃NO₅P
Molecular Weight:521.473
Hs Code.:

Synonyms:benzyl (2-(diethoxyphosphoryl)-1,1,1-trifluoro-5-phenylpent-4-yn-2-yl)(prop-2-yn-1-yl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2-(diethoxyphosphoryl)-1,1,1-trifluoro-5-phenylpent-4-yn-2-yl)(prop-2-yn-1-yl)carbamate

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Technology Process of benzyl (2-(diethoxyphosphoryl)-1,1,1-trifluoro-5-phenylpent-4-yn-2-yl)(prop-2-yn-1-yl)carbamate

There total 1 articles about benzyl (2-(diethoxyphosphoryl)-1,1,1-trifluoro-5-phenylpent-4-yn-2-yl)(prop-2-yn-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1228472-64-7
diethyl [1-{[(benzyloxy)carbonyl]amino}-4-phenyl-1-(trifluoromethyl)but-3-yn-1-yl]phosphonate

: 106-96-7
propargyl bromide

: 1452510-62-1
benzyl (2-(diethoxyphosphoryl)-1,1,1-trifluoro-5-phenylpent-4-yn-2-yl)(prop-2-yn-1-yl)carbamate

Guidance literature:: diethyl [1-{[(benzyloxy)carbonyl]amino}-4-phenyl-1-(trifluoromethyl)but-3-yn-1-yl]phosphonate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Inert atmosphere;

propargyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1055/s-0033-1339173

Reference yield:

: 1452510-62-1
benzyl (2-(diethoxyphosphoryl)-1,1,1-trifluoro-5-phenylpent-4-yn-2-yl)(prop-2-yn-1-yl)carbamate

: 693-02-7
hex-1-yne

: 1452510-64-3
benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1452510-93-8
benzyl 6-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 60 ℃; for 3h; Reagent/catalyst; Overall yield = 77 %; regioselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1339173

Reference yield:

: 629-05-0
n-octyne

: 1452510-62-1
benzyl (2-(diethoxyphosphoryl)-1,1,1-trifluoro-5-phenylpent-4-yn-2-yl)(prop-2-yn-1-yl)carbamate

: 1452510-83-6
benzyl 3-(diethoxyphosphoryl)-7-hexyl-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1452510-95-0
benzyl 3-(diethoxyphosphoryl)-6-hexyl-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 60 ℃; for 3h; Reagent/catalyst; Overall yield = 68 %; regioselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1339173