ethyl 4-(6-cyano-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)benzoate

Base Information

Chemical Name:ethyl 4-(6-cyano-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)benzoate
CAS No.:1272672-42-0
Molecular Formula:C₁₇H₁₃N₃O₄
Molecular Weight:323.308
Hs Code.:

Synonyms:ethyl 4-(6-cyano-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)benzoate

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Chemical Property of ethyl 4-(6-cyano-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)benzoate

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Technology Process of ethyl 4-(6-cyano-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)benzoate

There total 6 articles about ethyl 4-(6-cyano-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1272675-34-9
ethyl 3-[(cyanoacetyl)amino]-1-{4-[(ethyloxy)carbonyl]phenyl}-1H-pyrrole-2-carboxylate

: 1272672-42-0
ethyl 4-(6-cyano-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)benzoate

Guidance literature:: ethyl 3-[(cyanoacetyl)amino]-1-{4-[(ethyloxy)carbonyl]phenyl}-1H-pyrrole-2-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 50 ℃; for 36h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; mineral oil;

Reference yield:

: 252932-48-2
3-amino-2-ethoxycarbonylpyrrole

: 1272672-42-0
ethyl 4-(6-cyano-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: pyridine / copper diacetate / dichloromethane / 20 °C

3: hydrogenchloride; water / ethanol / 16 h / Reflux

4: dicyclohexyl-carbodiimide / acetonitrile / 48 h / 45 °C

5: sodium hydride / tetrahydrofuran; mineral oil / 36 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; water; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; copper diacetate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 252932-49-3
3-amino-2-ethoxycarbonylpyrrole hydrochloride

: 1272672-42-0
ethyl 4-(6-cyano-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: pyridine / copper diacetate / dichloromethane / 20 °C

3: hydrogenchloride; water / ethanol / 16 h / Reflux

4: dicyclohexyl-carbodiimide / acetonitrile / 48 h / 45 °C

5: sodium hydride / tetrahydrofuran; mineral oil / 36 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; water; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; copper diacetate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; mineral oil;