(R)-3-benzyl-1-((S)-1-phenylethyl)piperazine

Base Information

Chemical Name:(R)-3-benzyl-1-((S)-1-phenylethyl)piperazine
CAS No.:207690-56-0
Molecular Formula:C₁₉H₂₄N₂
Molecular Weight:280.413
Hs Code.:

Synonyms:(R)-3-benzyl-1-((S)-1-phenylethyl)piperazine

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Chemical Property of (R)-3-benzyl-1-((S)-1-phenylethyl)piperazine

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Technology Process of (R)-3-benzyl-1-((S)-1-phenylethyl)piperazine

There total 9 articles about (R)-3-benzyl-1-((S)-1-phenylethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: (R)-3-Benzyl-1-((S)-1-phenyl-ethyl)-piperazin-2-one; hydrochloride

: 207690-56-0
(R)-3-benzyl-1-((S)-1-phenylethyl)piperazine

Guidance literature:: With dimethylsulfide borane complex; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; for 1.5h; Heating;
DOI:10.1016/S0040-4020(98)00092-1

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 207690-56-0
(R)-3-benzyl-1-((S)-1-phenylethyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 4 Angstroem molecular sieves, 2.) NaCNBH₃ / 1.) THF, 0 deg C, 2 h, 2.) THF, overnight

2: 50 percent / HBTU, diisopropylethylamine / dimethylformamide

3: 72 percent / aq. TFA / 2 h / Ambient temperature

4: 52 percent / H₂ / Pd(OH)2/C / ethanol / 3.5 h / 2585.7 Torr / Ambient temperature

5: 61 percent / NaHCO₃, BMS / diethyl ether; tetrahydrofuran / 1.5 h / Heating

With dimethylsulfide borane complex; 4 A molecular sieve; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(98)00092-1

Reference yield:

: 207690-49-1
(S)-2,2-diethoxyethyl-(1-phenylethyl)amine

: 207690-56-0
(R)-3-benzyl-1-((S)-1-phenylethyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / HBTU, diisopropylethylamine / dimethylformamide

2: 72 percent / aq. TFA / 2 h / Ambient temperature

3: 52 percent / H₂ / Pd(OH)2/C / ethanol / 3.5 h / 2585.7 Torr / Ambient temperature

4: 61 percent / NaHCO₃, BMS / diethyl ether; tetrahydrofuran / 1.5 h / Heating

With dimethylsulfide borane complex; hydrogen; sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(98)00092-1