Technology Process of rac-2-benzyl-3-butenoic acid allyl ester
There total 1 articles about rac-2-benzyl-3-butenoic acid allyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
allyl vinylacetate;
With
lithium diisopropyl amide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
at -78 ℃;
for 1h;
benzyl bromide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
at -78 ℃;
for 1h;
DOI:10.1016/S0040-4020(02)00795-0
- Guidance literature:
-
With
phenylsilane;
tetrakis(triphenylphosphine) palladium(0);
In
dichloromethane;
for 0.5h;
DOI:10.1016/S0040-4020(02)00795-0
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 688 mg / PhSiH3 / (Ph3P)4Pd / CH2Cl2 / 0.5 h
2.1: 72 percent / Cl2CHOMe
3.1: BSA / CH2Cl2 / 1 h / 20 °C
3.2: 82 percent / CH2Cl2 / 0 - 20 °C
4.1: 42 percent / 1,3-(Mes)2-2-{[(Cy)3P]Ru(=CHPh)Cl2}-imidazolidine / benzene / 65 - 70 °C
5.1: 80 percent / TFA; Et3SiH / Heating
6.1: CH2Cl2 / 20 °C
With
triethylsilane; benzenesulfonamide; Dichloromethyl methyl ether; phenylsilane; trifluoroacetic acid;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tetrakis(triphenylphosphine) palladium(0);
In
dichloromethane; benzene;
DOI:10.1016/S0040-4020(02)00795-0
