(2R,4S,5R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-2,4-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

Base Information

Chemical Name:(2R,4S,5R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-2,4-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester
CAS No.:138058-66-9
Molecular Formula:C₂₉H₃₃NO₄
Molecular Weight:459.585
Hs Code.:

Synonyms:(2R,4S,5R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-2,4-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

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Chemical Property of (2R,4S,5R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-2,4-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

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Technology Process of (2R,4S,5R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-2,4-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

There total 7 articles about (2R,4S,5R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-2,4-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 100-39-0
benzyl bromide

: 138058-65-8
(2R,4S,5R)-2-((S)-2-Hydroxy-1-methyl-ethyl)-2,4-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

: 138058-66-9
(2R,4S,5R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-2,4-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: With silver(l) oxide; In diethyl ether; for 6h; Heating;
DOI:10.1016/S0040-4020(01)81947-5

Reference yield:

: 492-41-1,58550-13-3,757124-50-8
(1R,2S)-norephedrine

: 138058-66-9
(2R,4S,5R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-2,4-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / 2M NaOH / H₂O / Ambient temperature

2: 2) pyridinium tosylate / 1) benzene, reflux, 10 h, 2) reflux, 6 h

3: 57 percent / TiCl₄ / CH₂Cl₂ / 15 h / -20 °C

4: 65 percent / Na₂HPO₄, AgOTf / tetrahydrofuran / 3 h / Heating

5: 76 percent / LiBH₄ / diethyl ether; methanol / 2 h / Heating

6: 76 percent / Ag₂O / diethyl ether / 6 h / Heating

With sodium hydroxide; disodium hydrogenphosphate; lithium borohydride; silver trifluoromethanesulfonate; titanium tetrachloride; silver(l) oxide; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4020(01)81947-5

Reference yield:

: 104863-92-5
(1R,2S)-1-phenyl-2-benzyloxycarbonylamino-1-propanol

: 138058-66-9
(2R,4S,5R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-2,4-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 2) pyridinium tosylate / 1) benzene, reflux, 10 h, 2) reflux, 6 h

2: 57 percent / TiCl₄ / CH₂Cl₂ / 15 h / -20 °C

3: 65 percent / Na₂HPO₄, AgOTf / tetrahydrofuran / 3 h / Heating

4: 76 percent / LiBH₄ / diethyl ether; methanol / 2 h / Heating

5: 76 percent / Ag₂O / diethyl ether / 6 h / Heating

With disodium hydrogenphosphate; lithium borohydride; silver trifluoromethanesulfonate; titanium tetrachloride; silver(l) oxide; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(01)81947-5