dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-fluoropentanedioate

Base Information

Chemical Name:dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-fluoropentanedioate
CAS No.:1312438-59-7
Molecular Formula:C₂₂H₂₆FO₇P
Molecular Weight:452.416
Hs Code.:

Synonyms:dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-fluoropentanedioate

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Chemical Property of dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-fluoropentanedioate

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Technology Process of dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-fluoropentanedioate

There total 12 articles about dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-fluoropentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1312438-49-5
dimethyl (2S,4R)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)-pentanedioate

: 1312438-59-7
dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-fluoropentanedioate

Guidance literature:: With potassium fluoride; 18-crown-6 ether; In N,N-dimethyl-formamide; at 95 - 100 ℃; for 4h; Product distribution / selectivity; Microwave irradiation;

Reference yield: 31.0%

: 17176-77-1
Dibenzyl phosphite

: 1312438-93-9
dimethyl (S)-2-fluoro-4-methylenepentanedioate

: 1312438-60-0
dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-fluoropentanedioate

: 1312438-59-7
dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-fluoropentanedioate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Product distribution / selectivity; Microwave irradiation;

Reference yield:

: 1312438-70-2
dimethyl 2-hydroxy-4-methylenepentanedioate

: 1312438-59-7
dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-fluoropentanedioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 48 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Microwave irradiation

3.1: pyridinium p-toluenesulfonate / methanol / 2 h / 55 °C

3.2: 16 h / 20 °C

4.1: Chiralcel OD-H / hexane; ethanol / 20 °C / Resolution of racemate

5.1: potassium fluoride; 18-crown-6 ether / N,N-dimethyl-formamide / 4 h / 95 - 100 °C / Microwave irradiation

With potassium fluoride; 18-crown-6 ether; pyridinium p-toluenesulfonate; potassium carbonate; In methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;