5'-O-dimethoxytrityl-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite-2'-trifluoroacetamido-2'-deoxyuridine

Base Information

Chemical Name:5'-O-dimethoxytrityl-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite-2'-trifluoroacetamido-2'-deoxyuridine
CAS No.:126139-44-4
Molecular Formula:C₄₁H₄₇F₃N₅O₉P
Molecular Weight:841.821
Hs Code.:

Synonyms:5'-O-dimethoxytrityl-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite-2'-trifluoroacetamido-2'-deoxyuridine

Suppliers and Price of 5'-O-dimethoxytrityl-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite-2'-trifluoroacetamido-2'-deoxyuridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5'-O-dimethoxytrityl-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite-2'-trifluoroacetamido-2'-deoxyuridine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 5'-O-dimethoxytrityl-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite-2'-trifluoroacetamido-2'-deoxyuridine

There total 1 articles about 5'-O-dimethoxytrityl-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite-2'-trifluoroacetamido-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 118849-17-5
5'-O-(4,4'-dimethoxytrityl)-2'-(trifluoroacetylamido)-2'-deoxyuridine

: 126139-44-4
5'-O-dimethoxytrityl-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite-2'-trifluoroacetamido-2'-deoxyuridine

Guidance literature:: With (diisopropyl)bisammoniumtetrazolide; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.3987/com-03-s56

Reference yield:

: 126139-44-4
5'-O-dimethoxytrityl-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite-2'-trifluoroacetamido-2'-deoxyuridine

: 3'-[5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridyl]-5'-thymidilylphosphate ammonium salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-H-tetrazole / acetonitrile / 1 h / 20 °C

1.2: 90 percent / I₂; H₂O; 2,6-lutidine / acetonitrile; tetrahydrofuran / 1 h

2.1: 98 percent / NH₄OH / methanol / 24 h / 58 °C

3.1: 85 percent / TBAF / tetrahydrofuran / 12 h / 20 °C

With 1H-tetrazole; ammonium hydroxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.3987/com-03-s56

Reference yield:

: 126139-44-4
5'-O-dimethoxytrityl-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite-2'-trifluoroacetamido-2'-deoxyuridine

: 3'-[5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridyl]-5'-[3'-O-tert-butyldimethylsilylthymidilyl]phosphate ammonium salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-H-tetrazole / acetonitrile / 1 h / 20 °C

1.2: 90 percent / I₂; H₂O; 2,6-lutidine / acetonitrile; tetrahydrofuran / 1 h

2.1: 98 percent / NH₄OH / methanol / 24 h / 58 °C

With 1H-tetrazole; ammonium hydroxide; In methanol; acetonitrile;
DOI:10.3987/com-03-s56