(S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester

Base Information

Chemical Name:(S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester
CAS No.:212714-92-6
Molecular Formula:C₃₀H₃₆N₃O₁₃P
Molecular Weight:677.602
Hs Code.:

(S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester

Synonyms:(S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester

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Chemical Property of (S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester

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Technology Process of (S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester

There total 5 articles about (S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5680-86-4
N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid

: 212714-92-6
(S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / tetrahydrofuran / 0.5 h / 10 °C

2: NaBH₄ / H₂O; tetrahydrofuran / 4 h / Ambient temperature

3: tetrazole / acetonitrile / 5 h / Ambient temperature

4: aq. I₂ / pyridine; tetrahydrofuran

5: 97 percent / 90 percent aq. trifluoroacetic acid / 0.17 h / Ambient temperature

With 1H-tetrazole; sodium tetrahydroborate; iodine; triethylamine; trifluoroacetic acid; In tetrahydrofuran; pyridine; water; acetonitrile;
DOI:10.1006/bioo.1998.1082

Reference yield:

: 362-43-6
2',3'-O-isopropylideneuridine

: 212714-92-6
(S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / i-Pr₂EtN / CH₂Cl₂ / 0.2 h / Ambient temperature

2: tetrazole / acetonitrile / 5 h / Ambient temperature

3: aq. I₂ / pyridine; tetrahydrofuran

4: 97 percent / 90 percent aq. trifluoroacetic acid / 0.17 h / Ambient temperature

With 1H-tetrazole; iodine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; pyridine; dichloromethane; acetonitrile;
DOI:10.1006/bioo.1998.1082

Reference yield:

: 110559-89-2
benzyl 4-<(benzyloxycarbonyl)amino>-5-hydroxypentanoate

: 212714-92-6
(S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrazole / acetonitrile / 5 h / Ambient temperature

2: aq. I₂ / pyridine; tetrahydrofuran

3: 97 percent / 90 percent aq. trifluoroacetic acid / 0.17 h / Ambient temperature

With 1H-tetrazole; iodine; trifluoroacetic acid; In tetrahydrofuran; pyridine; acetonitrile;
DOI:10.1006/bioo.1998.1082