110559-89-2

Upstream product

• 56-86-0 L-glutamic acid 
• 501-53-1 benzyl chloroformate 
• 100-51-6 benzyl alcohol 
• 5680-86-4 N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid 
• 1676-73-9 L-glutamic acid γ-benzyl ester 

Downstream Products

• 212714-91-5 (S)-4-Benzyloxycarbonylamino-5-[((2R,3S,4R,5R)-3,4-dihydroxy-5-purin-9-yl-tetrahydro-furan-2-ylmethoxy)-methoxy-phosphoryloxy]-pentanoic acid benzyl ester 
• 212714-87-9 (S)-4-Benzyloxycarbonylamino-5-[((3aR,4R,6R,6aR)-2,2-dimethyl-6-purin-9-yl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy)-methoxy-phosphoryloxy]-pentanoic acid benzyl ester 
• 212714-92-6 (S)-4-Benzyloxycarbonylamino-5-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester 
• 212714-88-0 (S)-4-Benzyloxycarbonylamino-5-{[(3aR,4R,6R,6aR)-6-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-methoxy-phosphoryloxy}-pentanoic acid benzyl ester 
• 212714-90-4 (S)-5-{[(2R,3S,4R,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-4-benzyloxycarbonylamino-pentanoic acid benzyl ester 
• 212714-86-8 (S)-5-{[(3aR,4R,6R,6aR)-6-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-methoxy-phosphoryloxy}-4-benzyloxycarbonylamino-pentanoic acid benzyl ester 
• 212714-89-1 (S)-5-{[(2R,3S,4R,5R)-5-(6-Benzoylamino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-methoxy-phosphoryloxy}-4-benzyloxycarbonylamino-pentanoic acid benzyl ester 
• 212714-85-7 (S)-5-{[(3aR,4R,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-methoxy-phosphoryloxy}-4-benzyloxycarbonylamino-pentanoic acid benzyl ester 
• 1334145-40-2 C₃₆H₄₁NO₅Si 
• 1253792-91-4 (S)-4-amino-5-t-butyldiphenylsiloxyvaleric acid 

Relevant academic research and scientific papers

Asymmetric michael addition of malonates to enones catalyzed by a primary Β-amino acid and its lithium salt

Highly enantioselective Michael addition of malonates to enones was achieved using a mixed catalyst consisting of a primary Β-amino acid, O-TBDPS (S)-Β-homoserine, and its lithium salt. Various cyclic and acyclic enones were converted into 1,5-ketoesters in high yields (up to 92%) with high enantioselectivity (up to 97% ee) under mild reaction conditions. Details of synthesis of the catalyst, optimization of the reaction conditions for the Michael addition reaction, and a plausible reaction mechanism are described.

Glutamyl adenylate analogues are inhibitors of glutamyl-tRNA synthetase

Glutamol adenylate 10 was a competitive inhibitor (K(i) = 3 μM) of glutamyl-tRNA synthetase from Escherichia coli. The N6-benzoyl adenine derivative 9 was also an inhibitor (K(i) ~ 60 μM). Replacement of adenine by other bases (purine, cytosine