(-)-S-{5-[(2S,8S)-8-benzyl-5,5-dimethyl-3,6,9,15-tetraoxo-1,4,7,10-tetraazacyclopentadecan-2-yl]pentyl} octanethioate

Base Information

Chemical Name:(-)-S-{5-[(2S,8S)-8-benzyl-5,5-dimethyl-3,6,9,15-tetraoxo-1,4,7,10-tetraazacyclopentadecan-2-yl]pentyl} octanethioate
CAS No.:1429340-72-6
Molecular Formula:C₃₃H₅₂N₄O₅S
Molecular Weight:616.866
Hs Code.:

Synonyms:(-)-S-{5-[(2S,8S)-8-benzyl-5,5-dimethyl-3,6,9,15-tetraoxo-1,4,7,10-tetraazacyclopentadecan-2-yl]pentyl} octanethioate

Suppliers and Price of (-)-S-{5-[(2S,8S)-8-benzyl-5,5-dimethyl-3,6,9,15-tetraoxo-1,4,7,10-tetraazacyclopentadecan-2-yl]pentyl} octanethioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-S-{5-[(2S,8S)-8-benzyl-5,5-dimethyl-3,6,9,15-tetraoxo-1,4,7,10-tetraazacyclopentadecan-2-yl]pentyl} octanethioate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-S-{5-[(2S,8S)-8-benzyl-5,5-dimethyl-3,6,9,15-tetraoxo-1,4,7,10-tetraazacyclopentadecan-2-yl]pentyl} octanethioate

There total 14 articles about (-)-S-{5-[(2S,8S)-8-benzyl-5,5-dimethyl-3,6,9,15-tetraoxo-1,4,7,10-tetraazacyclopentadecan-2-yl]pentyl} octanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1429340-71-5
(-)-S-{5-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]pentyl} octanethioate

: 1429340-72-6
(-)-S-{5-[(2S,8S)-8-benzyl-5,5-dimethyl-3,6,9,15-tetraoxo-1,4,7,10-tetraazacyclopentadecan-2-yl]pentyl} octanethioate

Guidance literature:: With methanol; samarium diiodide; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jo4001492

Reference yield:

: (+)-(S)-butyl 2-{2-[(tert-butoxycarbonyl)amino]hept-6-enamido}-2-methylpropanoate

: 1429340-72-6
(-)-S-{5-[(2S,8S)-8-benzyl-5,5-dimethyl-3,6,9,15-tetraoxo-1,4,7,10-tetraazacyclopentadecan-2-yl]pentyl} octanethioate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 18 h / 20 °C / Cooling

2: 3 h / 0 °C

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide / N,N-dimethyl-formamide / 20 h / 20 °C

4: 2,2'-azobis(isobutyronitrile) / tetrahydrofuran / 16 h / Irradiation; Inert atmosphere; Reflux

5: samarium diiodide; methanol / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

With methanol; samarium diiodide; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; 2,2'-azobis(isobutyronitrile); benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo4001492

Reference yield:

: (-)-(3S,9S,14aR)-9-benzyl-3-(pent-4-enyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

: 1429340-72-6
(-)-S-{5-[(2S,8S)-8-benzyl-5,5-dimethyl-3,6,9,15-tetraoxo-1,4,7,10-tetraazacyclopentadecan-2-yl]pentyl} octanethioate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-azobis(isobutyronitrile) / tetrahydrofuran / 16 h / Irradiation; Inert atmosphere; Reflux

2: samarium diiodide; methanol / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

With methanol; samarium diiodide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran;
DOI:10.1021/jo4001492