<1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-1<<(1,1-Dimethyethyl)diphenylsilyl>oxy>-7-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-3,5-heptanediol

Base Information

• Chemical Name: <1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-1<<(1,1-Dimethyethyl)diphenylsilyl>oxy>-7-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-3,5-heptanediol
• CAS No.: 148933-92-0
• Molecular Formula: C₃₅H₅₀O₄Si
• Molecular Weight: 562.865
• Mol file: 148933-92-0.mol

Synonyms:<1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-1<<(1,1-Dimethyethyl)diphenylsilyl>oxy>-7-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-3,5-heptanediol

Chemical Property of <1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-1<<(1,1-Dimethyethyl)diphenylsilyl>oxy>-7-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-3,5-heptanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-1<<(1,1-Dimethyethyl)diphenylsilyl>oxy>-7-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-3,5-heptanediol

There total 2 articles about <1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-1<<(1,1-Dimethyethyl)diphenylsilyl>oxy>-7-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-3,5-heptanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

<1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-7-(1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-1,3,5-heptanetriol (148969-22-6) + tert-butylchlorodiphenylsilane (58479-61-1) → <1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-1<<(1,1-Dimethyethyl)diphenylsilyl>oxy>-7-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-3,5-heptanediol (148933-92-0)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1039/c39930000647

Reference yield:

lovastatin (75330-75-5,79952-44-6) → <1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-1<<(1,1-Dimethyethyl)diphenylsilyl>oxy>-7-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-3,5-heptanediol (148933-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / LiAlH₄ / tetrahydrofuran / 5 h

2: 100 percent / imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo00110a051

Reference yield: 82.0%

<1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-1<<(1,1-Dimethyethyl)diphenylsilyl>oxy>-7-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-3,5-heptanediol (148933-92-0) + acetone (67-64-1) → <1S-<1α,3α,7β,8β(4S*,6R*),8aβ>>-8-<2-<6-<2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl>-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenol (116996-45-3)

Guidance literature:

With toluene-4-sulfonic acid;

DOI:10.1039/c39930000647

upstream raw materials:

<1S-<1α(3R*,5S*),2α,6β,8β,8aα>>-7-(1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)-1,3,5-heptanetriol

tert-butylchlorodiphenylsilane

lovastatin

Downstream raw materials:

<1S-<1α,3α,7β,8β(4S^*,6R^*),8aβ>>-8-<2-<6-<2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl>-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenol

<4R-<4α(4R^*,5R^*),6α>>-5-<2-<6-<2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl>-4-methyl-2-cyclohexen-1-one

<1aR-<1aα,2β,4β,4aα,5α(4R*,6S*),6α>>-5-<2-<6-<2-<<(1,1-Dimethylethyl)diphenylsilyl>oxy>ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl>-1a,2,4,4a,5,6-hexahydro-2,6-dimethyl-3H-naphth<1,8a-b>oxiren-4-ol

(3R,7S,8S,8aR)-8-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3,7-dimethyl-3,7,8,8a-tetrahydro-2H-naphthalen-1-one