BUTYRIC-3,3-D2 ACID

Base Information

• Chemical Name: BUTYRIC-3,3-D2 ACID
• CAS No.: 64833-96-1
• Molecular Formula: C₄H₈O₂
• Molecular Weight: 90.0904
• Mol file: 64833-96-1.mol

Synonyms:BUTYRIC-3,3-D2 ACID

Chemical Property of BUTYRIC-3,3-D2 ACID

Chemical Property:

• PSA: 37.30000
• LogP: 0.87110

Purity/Quality:

Butyric-3,3-d2Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Butyric-3,3-d2 Acid (CAS# 64833-96-1) is a useful isotopically labeled research compound.

Technology Process of BUTYRIC-3,3-D2 ACID

There total 4 articles about BUTYRIC-3,3-D2 ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

1,1-dideuterio-1-bromoethane (3652-84-4) + acetic acid (64-19-7,77671-22-8) → (3,3-2H2)-butyric acid (64833-96-1)

Guidance literature:

acetic acid; With lithium diisopropyl amide; In tetrahydrofuran; at -40 - 0 ℃; for 0.5h; Inert atmosphere;

1,1-dideuterio-1-bromoethane; In tetrahydrofuran; hexane; at -40 - 20 ℃; for 5h; Inert atmosphere;

Reference yield:

1-(3,3-2H2)-butanol (64118-20-3) → (3,3-2H2)-butyric acid (64833-96-1)

Guidance literature:

With sodium dichromate; sulfuric acid;

DOI:10.1021/ja00416a003

Reference yield:

1-iodopropane-2,2-d2 (25493-15-6) + carbon dioxide (124-38-9,18923-20-1) → (3,3-2H2)-butyric acid (64833-96-1)

Guidance literature:

With magnesium; Multistep reaction; 1.) Et₂O, 2.) -78 deg C;

DOI:10.1002/oms.1210281035

upstream raw materials:

1-iodopropane-2,2-d₂

carbon dioxide

1-(3,3-2H₂)-butanol

1,1-dideuterio-1-bromoethane

Refernces

• 1、 Bowen, Richard D.,Suh, Dennis,Terlouw, Johan K.. "Reactions of Ionized Dibutyl Ether". . p. 791 - 805. Retrieved 2007/10/02.
• 2、 McAdoo, David J.,Hudson, Charles E.. "Noncompeting Metastable Losses of Methyl and Ethylene from Gaseous Butanoic Acid Ions due to Isomerization Prior to Methyl Loss". . p. 7710 - 7713. Retrieved 2007/10/02.