2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

Base Information

Chemical Name:2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester
CAS No.:642087-19-2
Molecular Formula:C₂₀H₃₂NO₇P
Molecular Weight:429.45
Hs Code.:

2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid <i>tert</i>-butyl ester

Synonyms:2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

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Chemical Property of 2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

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Technology Process of 2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

There total 1 articles about 2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 3095-95-2
diethylphosphonoacetic acid

: 281190-95-2
(R)-tert-butyl 2-amino-3-(4-methoxyphenyl)propionate

: 642087-19-2
2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 23 ℃; for 1h;
DOI:10.1021/jo035077v

Reference yield:

: 642087-19-2
2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

: 642087-13-6
3-(diethoxyphosphinyl)-N-(3-chloro-4-methoxyphenyl)-D-alanine tert-butyl ester

Guidance literature:: With Oxone; potassium chloride; In water; acetonitrile; at 23 ℃; for 5h;
DOI:10.1021/jo035077v

Reference yield:

: 642087-19-2
2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

: 186256-66-6
cryptophycin-51

Guidance literature:: Multi-step reaction with 5 steps

1.1: KCl; oxone / acetonitrile; H₂O / 5 h / 23 °C

2.1: NaH / tetrahydrofuran / 1 h / 0 °C

2.2: 109 mg / tetrahydrofuran / 1.5 h

3.1: 229 mg / Et₃N; DMAP / toluene / 0.5 h / 23 °C

4.1: CF₃COOH / CH₂Cl₂ / 0 - 20 °C

5.1: 57 mg / pentafluorophenyl diphenylphosphinate; i-Pr₂NEt / dimethylformamide / 12 h / 23 °C

With dmap; Oxone; pentafluorophenyl diphenyl-phosphinate; potassium chloride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 2.2: Horner-Emmons reaction;
DOI:10.1021/jo035077v