6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid methyl ester

Base Information

• Chemical Name: 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid methyl ester
• CAS No.: 84969-38-0
• Molecular Formula: C₂₇H₄₃N₃O₆
• Molecular Weight: 505.655

Synonyms:6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid methyl ester

Chemical Property of 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid methyl ester

Chemical Property:

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Technology Process of 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid methyl ester

There total 4 articles about 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

tert-butoxycarbonyl-L-phenylalanyl-L-leucine (33014-68-5) + methyl 6-aminocaproate hydrochloride (1926-80-3) → 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid methyl ester (84969-38-0)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

DOI:10.1002/recl.19821011206

Reference yield:

(S)-Leu-OMe (2666-93-5) → 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid methyl ester (84969-38-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent

2: 71 percent / aq. NaOH / dioxane

3: 70 percent / DCC, HOBt

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1002/recl.19821011206

Reference yield:

N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester (7535-56-0) → 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid methyl ester (84969-38-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent

2: 71 percent / aq. NaOH / dioxane

3: 70 percent / DCC, HOBt

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1002/recl.19821011206

upstream raw materials:

tert-butoxycarbonyl-L-phenylalanyl-L-leucine

methyl 6-aminocaproate hydrochloride

(S)-Leu-OMe

N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester

Downstream raw materials:

6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid

6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-hexanoic acid 4-nitro-phenyl ester

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