(+/-)-3-(1-benzoylpiperidin-4-yl)2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Base Information

Chemical Name:(+/-)-3-(1-benzoylpiperidin-4-yl)2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol
CAS No.:1253197-50-0
Molecular Formula:C₂₂H₂₆N₂O₃
Molecular Weight:366.46
Hs Code.:

Synonyms:(+/-)-3-(1-benzoylpiperidin-4-yl)2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

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Chemical Property of (+/-)-3-(1-benzoylpiperidin-4-yl)2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

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Technology Process of (+/-)-3-(1-benzoylpiperidin-4-yl)2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

There total 8 articles about (+/-)-3-(1-benzoylpiperidin-4-yl)2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1253197-51-1
(+/-)-3-(1-benzoylpiperidin-4-yl)-7-benzyloxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 1253197-50-0
(+/-)-3-(1-benzoylpiperidin-4-yl)2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h; under 750.075 Torr;
DOI:10.1016/j.bmc.2010.09.026

Reference yield:

: 1253197-29-3
(+/-)-7-benzyloxy-3-(4-tosyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 1253197-50-0
(+/-)-3-(1-benzoylpiperidin-4-yl)2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; magnesium / 5 h / Reflux

2: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With methanol; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; magnesium; In methanol; dichloromethane;

Reference yield:

: ethyl 2-{N-[2-(3-methoxyphenyl)ethyl]4-methylbenzenesulfonamido}acetate

: 1253197-50-0
(+/-)-3-(1-benzoylpiperidin-4-yl)2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; water / ethanol / 5 h / Reflux

2.1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere

3.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

3.2: 1 h / Cooling with ice

4.1: potassium carbonate / acetone / 4 h / Reflux

5.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

6.1: methanol; magnesium / 5 h / Reflux

7.1: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C

8.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus pentoxide; palladium 10% on activated carbon; water; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; magnesium; sodium hydroxide; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; acetone;